Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 71318..71902 Replicon plasmid pGX7
Accession NZ_CP071772
Organism Acinetobacter towneri strain GX7

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J4G46_RS14020 Protein ID WP_154320144.1
Coordinates 71600..71902 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag J4G46_RS14015 Protein ID WP_000985610.1
Coordinates 71318..71599 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G46_RS14000 (J4G46_14000) 68155..69318 - 1164 WP_032073150.1 efflux RND transporter periplasmic adaptor subunit -
J4G46_RS14005 (J4G46_14005) 69745..70341 + 597 WP_074163998.1 LysE family transporter -
J4G46_RS14010 (J4G46_14010) 70369..71187 - 819 WP_032073151.1 AraC family transcriptional regulator -
J4G46_RS14015 (J4G46_14015) 71318..71599 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
J4G46_RS14020 (J4G46_14020) 71600..71902 - 303 WP_154320144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G46_RS14025 (J4G46_14025) 72152..72361 + 210 WP_004976362.1 hypothetical protein -
J4G46_RS14030 (J4G46_14030) 72611..74065 + 1455 WP_026438532.1 SulP family inorganic anion transporter -
J4G46_RS14035 (J4G46_14035) 74176..74466 - 291 WP_004969304.1 putative addiction module antidote protein -
J4G46_RS14040 (J4G46_14040) 74468..74764 - 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4G46_RS14655 74981..75106 + 126 WP_004969301.1 hypothetical protein -
J4G46_RS14045 (J4G46_14045) 75200..76282 - 1083 WP_004969299.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / erm(B) / blaOXA-58 / floR / sul2 / tet(X3) / aph(3')-Ia - 1..178739 178739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11558.10 Da        Isoelectric Point: 4.6838

>T196906 WP_154320144.1 NZ_CP071772:c71902-71600 [Acinetobacter towneri]
MYSIYTTEVFDDWFTKLKDLQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T196906 NZ_CP095510:2862106-2862384 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT196906 WP_000985610.1 NZ_CP071772:c71599-71318 [Acinetobacter towneri]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT196906 NZ_CP095510:2862384-2862668 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References