Detailed information of TA system TA196904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2419309..2419958
• Replicon: chromosome
• Accession: NZ_CP071771
• Organism: Acinetobacter towneri strain GX7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: N9B9L0
• Locus tag: J4G46_RS11625
• Protein ID: WP_004972405.1
• Coordinates: 2419309..2419728 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: N9CPX4
• Locus tag: J4G46_RS11630
• Protein ID: WP_004972406.1
• Coordinates: 2419728..2419958 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4G46_RS11595 (J4G46_11595)	2414678..2415343	-	666	WP_180059923.1	pseudouridine synthase	-
J4G46_RS11600 (J4G46_11600)	2415537..2416250	-	714	WP_178319260.1	SIMPL domain-containing protein	-
J4G46_RS11605 (J4G46_11605)	2416352..2416603	-	252	WP_004972400.1	hypothetical protein	-
J4G46_RS11615 (J4G46_11615)	2418356..2418928	-	573	WP_096901555.1	DUF4126 domain-containing protein	-
J4G46_RS11620 (J4G46_11620)	2419035..2419178	-	144	WP_004972403.1	zinc ribbon-containing protein	-
J4G46_RS11625 (J4G46_11625)	2419309..2419728	-	420	WP_004972405.1	type II toxin-antitoxin system VapC family toxin	Toxin
J4G46_RS11630 (J4G46_11630)	2419728..2419958	-	231	WP_004972406.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
J4G46_RS11635 (J4G46_11635)	2420255..2422861	-	2607	WP_208011928.1	Fe/S-dependent 2-methylisocitrate dehydratase AcnD	-
J4G46_RS11640 (J4G46_11640)	2423118..2423840	+	723	WP_004972410.1	folate-binding protein YgfZ	-
J4G46_RS11645 (J4G46_11645)	2424027..2424833	+	807	WP_131260788.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-128)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16147.60 Da
• Isoelectric Point: 7.1858

>T196904 WP_004972405.1 NZ_CP071771:c2419728-2419309 [Acinetobacter towneri]
MQVQYLLDTNICIYIIKYRPEIVRQHFEKHLPHRNILISVITLGELRFGAEKSQHKEKALKVIDELTSMIQVVELDENVA
HHYAEIRQNLASKGQIIGANDLWLAAHARANHWVMVTNNEKEFTRVDGLKVENWVSNPL

Nucleotide

• Length: 420 bp

>T196904 NZ_CP095510:2454629-2454732 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9068.42 Da
• Isoelectric Point: 5.1972

>AT196904 WP_004972406.1 NZ_CP071771:c2419958-2419728 [Acinetobacter towneri]
MTTAKVFMTGRSQAIRLPKEFRFEGKEVEIFRRGDEVILREKPVTVDRLFKALSQMPNDFYADEREDLPPQEREMF

Nucleotide

• Length: 231 bp

>AT196904 NZ_CP095510:c2454770-2454499 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: N9B9L0

Antitoxin

• AlphaFold DB: N9CPX4