Detailed information of TA system TA196902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1613310..1613884
• Replicon: chromosome
• Accession: NZ_CP071771
• Organism: Acinetobacter towneri strain GX7

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: N9B925
• Locus tag: J4G46_RS07675
• Protein ID: WP_004973562.1
• Coordinates: 1613310..1613498 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9B7X5
• Locus tag: J4G46_RS07680
• Protein ID: WP_004973564.1
• Coordinates: 1613501..1613884 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4G46_RS07640 (J4G46_07640)	1608542..1609030	+	489	WP_004973550.1	helix-turn-helix domain-containing protein	-
J4G46_RS07645 (J4G46_07645)	1609062..1609373	-	312	WP_208011749.1	TusE/DsrC/DsvC family sulfur relay protein	-
J4G46_RS07650 (J4G46_07650)	1609432..1609716	-	285	WP_004973553.1	DsrH/TusB family sulfur metabolism protein	-
J4G46_RS07655 (J4G46_07655)	1609782..1610132	-	351	WP_167846018.1	hypothetical protein	-
J4G46_RS07660 (J4G46_07660)	1610176..1610544	-	369	WP_154320742.1	sulfurtransferase complex subunit TusD	-
J4G46_RS07665 (J4G46_07665)	1610605..1611609	+	1005	WP_208011750.1	SDR family NAD(P)-dependent oxidoreductase	-
J4G46_RS07670 (J4G46_07670)	1611783..1613177	+	1395	WP_179995488.1	class II fumarate hydratase	-
J4G46_RS07675 (J4G46_07675)	1613310..1613498	+	189	WP_004973562.1	type II toxin-antitoxin system HicA family toxin	Toxin
J4G46_RS07680 (J4G46_07680)	1613501..1613884	+	384	WP_004973564.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J4G46_RS07685 (J4G46_07685)	1614260..1614751	+	492	WP_004973565.1	hypothetical protein	-
J4G46_RS07690 (J4G46_07690)	1614855..1615772	-	918	WP_179990769.1	LysR family transcriptional regulator	-
J4G46_RS07695 (J4G46_07695)	1615866..1617107	+	1242	WP_004973568.1	acyl-CoA dehydrogenase family protein	-
J4G46_RS07700 (J4G46_07700)	1617238..1618359	+	1122	WP_179994188.1	phosphotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7350.46 Da
• Isoelectric Point: 10.2954

>T196902 WP_004973562.1 NZ_CP071771:1613310-1613498 [Acinetobacter towneri]
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKPGHVVVPHPRKDMPIGTLRNIYKQAGWEWR

Nucleotide

• Length: 189 bp

>T196902 NZ_CP095510:2244025-2244279 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14346.19 Da
• Isoelectric Point: 4.3695

>AT196902 WP_004973564.1 NZ_CP071771:1613501-1613884 [Acinetobacter towneri]
MLYPVYVHKDEDSAYGLTFPDFDGCFSAADEMQDIQRMAQEAVEVHFDGEDIPLPEPSSPEQWLGDERFEGGFWLLVDID
TTKVNTKSIRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAEMALH

Nucleotide

• Length: 384 bp

>AT196902 NZ_CP095510:2243777-2244028 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: N9B925

Antitoxin

• AlphaFold DB: N9B7X5