Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2158870..2159519 Replicon chromosome
Accession NZ_CP071770
Organism Acinetobacter towneri strain GX5

Toxin (Protein)


Gene name vapC Uniprot ID N9B9L0
Locus tag J4G45_RS11415 Protein ID WP_004972405.1
Coordinates 2158870..2159289 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID N9CPX4
Locus tag J4G45_RS11420 Protein ID WP_004972406.1
Coordinates 2159289..2159519 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G45_RS11385 (J4G45_11390) 2154221..2155171 - 951 WP_228291706.1 DUF5660 domain-containing protein -
J4G45_RS11390 (J4G45_11395) 2155451..2156116 - 666 WP_180059923.1 pseudouridine synthase -
J4G45_RS11395 (J4G45_11400) 2156268..2156981 - 714 WP_004972399.1 SIMPL domain-containing protein -
J4G45_RS11400 (J4G45_11405) 2157101..2157352 - 252 WP_004972400.1 hypothetical protein -
J4G45_RS11405 (J4G45_11410) 2157916..2158488 - 573 WP_019837767.1 DUF4126 domain-containing protein -
J4G45_RS11410 (J4G45_11415) 2158596..2158739 - 144 WP_096901556.1 hypothetical protein -
J4G45_RS11415 (J4G45_11420) 2158870..2159289 - 420 WP_004972405.1 type II toxin-antitoxin system VapC family toxin Toxin
J4G45_RS11420 (J4G45_11425) 2159289..2159519 - 231 WP_004972406.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J4G45_RS11425 (J4G45_11430) 2159816..2162422 - 2607 WP_096901558.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
J4G45_RS11430 (J4G45_11435) 2162679..2163401 + 723 WP_004972410.1 folate-binding protein YgfZ -
J4G45_RS11435 (J4G45_11440) 2163593..2164399 + 807 WP_026438287.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16147.60 Da        Isoelectric Point: 7.1858

>T196898 WP_004972405.1 NZ_CP071770:c2159289-2158870 [Acinetobacter towneri]
MQVQYLLDTNICIYIIKYRPEIVRQHFEKHLPHRNILISVITLGELRFGAEKSQHKEKALKVIDELTSMIQVVELDENVA
HHYAEIRQNLASKGQIIGANDLWLAAHARANHWVMVTNNEKEFTRVDGLKVENWVSNPL

Download         Length: 420 bp

>T196898 NZ_CP095510:986470-986766 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9068.42 Da        Isoelectric Point: 5.1972

>AT196898 WP_004972406.1 NZ_CP071770:c2159519-2159289 [Acinetobacter towneri]
MTTAKVFMTGRSQAIRLPKEFRFEGKEVEIFRRGDEVILREKPVTVDRLFKALSQMPNDFYADEREDLPPQEREMF

Download         Length: 231 bp

>AT196898 NZ_CP095510:986768-987163 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9B9L0

Antitoxin

Source ID Structure
AlphaFold DB N9CPX4

References