Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1455114..1455688 | Replicon | chromosome |
| Accession | NZ_CP071770 | ||
| Organism | Acinetobacter towneri strain GX5 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | N9B925 |
| Locus tag | J4G45_RS07895 | Protein ID | WP_004973562.1 |
| Coordinates | 1455114..1455302 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9B7X5 |
| Locus tag | J4G45_RS07900 | Protein ID | WP_004973564.1 |
| Coordinates | 1455305..1455688 (+) | Length | 128 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4G45_RS07860 (J4G45_07865) | 1450346..1450834 | + | 489 | WP_004973550.1 | helix-turn-helix domain-containing protein | - |
| J4G45_RS07865 (J4G45_07870) | 1450866..1451177 | - | 312 | WP_026438386.1 | TusE/DsrC/DsvC family sulfur relay protein | - |
| J4G45_RS07870 (J4G45_07875) | 1451236..1451520 | - | 285 | WP_004973553.1 | DsrH/TusB family sulfur metabolism protein | - |
| J4G45_RS07875 (J4G45_07880) | 1451586..1451936 | - | 351 | WP_180158927.1 | hypothetical protein | - |
| J4G45_RS07880 (J4G45_07885) | 1451980..1452348 | - | 369 | WP_154320742.1 | sulfurtransferase complex subunit TusD | - |
| J4G45_RS07885 (J4G45_07890) | 1452409..1453413 | + | 1005 | WP_096902815.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| J4G45_RS07890 (J4G45_07895) | 1453587..1454981 | + | 1395 | WP_167846017.1 | class II fumarate hydratase | - |
| J4G45_RS07895 (J4G45_07900) | 1455114..1455302 | + | 189 | WP_004973562.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| J4G45_RS07900 (J4G45_07905) | 1455305..1455688 | + | 384 | WP_004973564.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| J4G45_RS07905 (J4G45_07910) | 1456064..1456555 | + | 492 | WP_004973565.1 | hypothetical protein | - |
| J4G45_RS07910 (J4G45_07915) | 1456660..1457577 | - | 918 | WP_104851971.1 | LysR family transcriptional regulator | - |
| J4G45_RS07915 (J4G45_07920) | 1457670..1458911 | + | 1242 | WP_207973576.1 | acyl-CoA dehydrogenase family protein | - |
| J4G45_RS07920 (J4G45_07925) | 1459042..1460163 | + | 1122 | WP_179994188.1 | phosphotransferase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7350.46 Da Isoelectric Point: 10.2954
>T196896 WP_004973562.1 NZ_CP071770:1455114-1455302 [Acinetobacter towneri]
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKPGHVVVPHPRKDMPIGTLRNIYKQAGWEWR
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKPGHVVVPHPRKDMPIGTLRNIYKQAGWEWR
Download Length: 189 bp
>T196896 NZ_CP095510:c880496-880032 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGGCAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCTTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGGCAGAAGAAACCCATTGA
Antitoxin
Download Length: 128 a.a. Molecular weight: 14346.19 Da Isoelectric Point: 4.3695
>AT196896 WP_004973564.1 NZ_CP071770:1455305-1455688 [Acinetobacter towneri]
MLYPVYVHKDEDSAYGLTFPDFDGCFSAADEMQDIQRMAQEAVEVHFDGEDIPLPEPSSPEQWLGDERFEGGFWLLVDID
TTKVNTKSIRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAEMALH
MLYPVYVHKDEDSAYGLTFPDFDGCFSAADEMQDIQRMAQEAVEVHFDGEDIPLPEPSSPEQWLGDERFEGGFWLLVDID
TTKVNTKSIRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAEMALH
Download Length: 384 bp
>AT196896 NZ_CP095510:c880831-880496 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACACC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACACC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|