Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 966731..967259 Replicon chromosome
Accession NZ_CP071770
Organism Acinetobacter towneri strain GX5

Toxin (Protein)


Gene name relE Uniprot ID N9CJV8
Locus tag J4G45_RS05465 Protein ID WP_004970510.1
Coordinates 966731..967024 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4G45_RS05470 Protein ID WP_104852301.1
Coordinates 967014..967259 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G45_RS05425 (J4G45_05430) 962082..962576 + 495 WP_004970523.1 flavin reductase -
J4G45_RS05430 (J4G45_05435) 962648..962938 + 291 WP_019836372.1 type II toxin-antitoxin system HigB family toxin -
J4G45_RS05435 (J4G45_05440) 962940..963341 + 402 WP_004970519.1 helix-turn-helix domain-containing protein -
J4G45_RS05445 (J4G45_05450) 963682..963966 - 285 WP_004970518.1 cell division protein ZapA -
J4G45_RS05450 (J4G45_05455) 963968..964519 - 552 WP_207973654.1 hypothetical protein -
J4G45_RS05455 (J4G45_05460) 964584..965222 + 639 WP_179996074.1 UPF0149 family protein -
J4G45_RS05460 (J4G45_05465) 965317..966651 + 1335 WP_154320488.1 Xaa-Pro aminopeptidase -
J4G45_RS05465 (J4G45_05470) 966731..967024 - 294 WP_004970510.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G45_RS05470 (J4G45_05475) 967014..967259 - 246 WP_104852301.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J4G45_RS05475 (J4G45_05480) 967632..968840 + 1209 WP_179990342.1 2-octaprenyl-6-methoxyphenyl hydroxylase -
J4G45_RS05480 (J4G45_05485) 968837..970087 + 1251 WP_207973653.1 FAD-dependent monooxygenase -
J4G45_RS05485 (J4G45_05490) 970264..970512 + 249 WP_207973652.1 hypothetical protein -
J4G45_RS05490 (J4G45_05495) 970705..971547 - 843 WP_179991266.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
J4G45_RS05495 (J4G45_05500) 971753..972181 + 429 WP_004972647.1 YraN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-74)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11279.44 Da        Isoelectric Point: 10.3743

>T196894 WP_004970510.1 NZ_CP071770:c967024-966731 [Acinetobacter towneri]
MTYNLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLIYQVKDDQVVILLITVG
KRADNIVYDEAKKRIKD

Download         Length: 294 bp

>T196894 NZ_CP095506:c54682-54533 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9247.60 Da        Isoelectric Point: 4.3885

>AT196894 WP_104852301.1 NZ_CP071770:c967259-967014 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGISPTDFFTNILEYVATTGKLPVHKALLSEEDAELLALVRKRMNDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT196894 NZ_CP095506:54730-54786 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9CJV8

Antitoxin

Source ID Structure

References