Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 428375..428955 Replicon chromosome
Accession NZ_CP071770
Organism Acinetobacter towneri strain GX5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J4G45_RS02910 Protein ID WP_207973761.1
Coordinates 428375..428623 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9B896
Locus tag J4G45_RS02915 Protein ID WP_004974672.1
Coordinates 428620..428955 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G45_RS02885 (J4G45_02885) 423672..424274 + 603 WP_026438479.1 TIGR00730 family Rossman fold protein -
J4G45_RS02890 (J4G45_02890) 424276..424686 + 411 WP_004974664.1 NUDIX domain-containing protein -
J4G45_RS02895 (J4G45_02895) 424761..425396 - 636 WP_154320297.1 phosphoribosyltransferase family protein -
J4G45_RS02900 (J4G45_02900) 425415..427460 - 2046 WP_180044029.1 ATP-dependent DNA helicase RecG -
J4G45_RS02905 (J4G45_02905) 427497..428276 + 780 WP_004974669.1 NAD(P)H-binding protein -
J4G45_RS02910 (J4G45_02910) 428375..428623 + 249 WP_207973761.1 type II toxin-antitoxin system HicA family toxin Toxin
J4G45_RS02915 (J4G45_02915) 428620..428955 + 336 WP_004974672.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J4G45_RS02920 (J4G45_02920) 429046..431610 - 2565 WP_004974675.1 glycerol-3-phosphate 1-O-acyltransferase PlsB -
J4G45_RS02925 (J4G45_02925) 431915..432787 + 873 WP_004974677.1 acyl-CoA thioesterase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9388.02 Da        Isoelectric Point: 10.2183

>T196893 WP_207973761.1 NZ_CP071770:428375-428623 [Acinetobacter towneri]
MGKTEKLLDKIGNSKNTFPYKDLVVLLSQLGYEKFEMAGSRVRFYNLKTEHMILLHRPHPENEIKGGALKAVKQALKQEG
FL

Download         Length: 249 bp

>T196893 NZ_CP095505:c4780664-4780557 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12488.22 Da        Isoelectric Point: 4.5942

>AT196893 WP_004974672.1 NZ_CP071770:428620-428955 [Acinetobacter towneri]
MSYFKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKTLEQAFQESVDGYLDSCAELGKKPDQPFKGTFNVRISPE
LHRKAVLASEESSLNAFVSDAIQEKLMRLGV

Download         Length: 336 bp

>AT196893 NZ_CP095505:4780712-4780778 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB N9B896

References