Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 156781..157309 | Replicon | plasmid pGX5 |
| Accession | NZ_CP071769 | ||
| Organism | Acinetobacter towneri strain GX5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | N8SCV7 |
| Locus tag | J4G45_RS00780 | Protein ID | WP_004733298.1 |
| Coordinates | 156781..157074 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A1E8E1G7 |
| Locus tag | J4G45_RS00785 | Protein ID | WP_070154357.1 |
| Coordinates | 157064..157309 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4G45_RS00740 (J4G45_00735) | 152727..153041 | - | 315 | WP_104505826.1 | hypothetical protein | - |
| J4G45_RS00745 (J4G45_00740) | 153080..153394 | - | 315 | WP_104505827.1 | helix-turn-helix domain-containing protein | - |
| J4G45_RS00750 (J4G45_00745) | 153375..153698 | - | 324 | WP_104505828.1 | transcriptional regulator | - |
| J4G45_RS00755 (J4G45_00750) | 153778..153882 | + | 105 | Protein_152 | transposase domain-containing protein | - |
| J4G45_RS00760 (J4G45_00755) | 154016..154429 | + | 414 | WP_207973977.1 | hypothetical protein | - |
| J4G45_RS00765 (J4G45_00760) | 154432..154746 | + | 315 | WP_070155405.1 | hypothetical protein | - |
| J4G45_RS00770 (J4G45_00765) | 154917..156242 | - | 1326 | WP_096902756.1 | ISNCY family transposase | - |
| J4G45_RS00775 (J4G45_00770) | 156387..156689 | - | 303 | WP_136144098.1 | hypothetical protein | - |
| J4G45_RS00780 (J4G45_00775) | 156781..157074 | - | 294 | WP_004733298.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J4G45_RS00785 (J4G45_00780) | 157064..157309 | - | 246 | WP_070154357.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| J4G45_RS00795 (J4G45_00790) | 159006..159428 | - | 423 | WP_004676061.1 | hypothetical protein | - |
| J4G45_RS00800 (J4G45_00795) | 159532..159855 | + | 324 | WP_004676058.1 | hypothetical protein | - |
| J4G45_RS00805 (J4G45_00800) | 160031..160642 | + | 612 | WP_015060246.1 | recombinase family protein | - |
| J4G45_RS00810 (J4G45_00805) | 160832..161716 | - | 885 | WP_000155092.1 | Mph(E) family macrolide 2'-phosphotransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | floR / sul2 / dfrA20 / tet(X3) / aph(3')-Ia / mph(E) / msr(E) / blaOXA-58 | - | 1..178808 | 178808 | |
| - | inside | IScluster/Tn | mph(E) / msr(E) / blaOXA-58 | - | 145341..173460 | 28119 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11252.46 Da Isoelectric Point: 10.4456
>T196890 WP_004733298.1 NZ_CP071769:c157074-156781 [Acinetobacter towneri]
MTYKLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
MTYKLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
Download Length: 294 bp
>T196890 NZ_CP095505:3871768-3872166 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACAGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACAGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9204.56 Da Isoelectric Point: 4.2703
>AT196890 WP_070154357.1 NZ_CP071769:c157309-157064 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGIAPTEFFTNILEYIATTGKLPVQKALLSEEDADLLALVRKRVNDPKEMFEEVTLDD
L
MATVNFRVDEALKEKSYSILKEQGIAPTEFFTNILEYIATTGKLPVQKALLSEEDADLLALVRKRVNDPKEMFEEVTLDD
L
Download Length: 246 bp
>AT196890 NZ_CP095505:3871472-3871765 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | N8SCV7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E8E1G7 |