Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4758..5342 Replicon plasmid pGX5
Accession NZ_CP071769
Organism Acinetobacter towneri strain GX5

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J4G45_RS00030 Protein ID WP_154320144.1
Coordinates 5040..5342 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag J4G45_RS00025 Protein ID WP_000985610.1
Coordinates 4758..5039 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G45_RS00010 (J4G45_00010) 1595..2758 - 1164 WP_032073150.1 efflux RND transporter periplasmic adaptor subunit -
J4G45_RS00015 (J4G45_00015) 3185..3781 + 597 WP_074163998.1 LysE family transporter -
J4G45_RS00020 (J4G45_00020) 3809..4627 - 819 WP_179989168.1 AraC family transcriptional regulator -
J4G45_RS00025 (J4G45_00025) 4758..5039 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
J4G45_RS00030 (J4G45_00030) 5040..5342 - 303 WP_154320144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G45_RS00035 (J4G45_00035) 5592..5801 + 210 WP_004976362.1 hypothetical protein -
J4G45_RS00040 (J4G45_00040) 6051..7505 + 1455 WP_026438532.1 SulP family inorganic anion transporter -
J4G45_RS00045 (J4G45_00045) 7616..7906 - 291 WP_004969304.1 putative addiction module antidote protein -
J4G45_RS00050 (J4G45_00050) 7908..8204 - 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4G45_RS13740 8421..8546 + 126 WP_004969301.1 hypothetical protein -
J4G45_RS00055 (J4G45_00055) 8640..9722 - 1083 WP_004969299.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR / sul2 / dfrA20 / tet(X3) / aph(3')-Ia / mph(E) / msr(E) / blaOXA-58 - 1..178808 178808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11558.10 Da        Isoelectric Point: 4.6838

>T196888 WP_154320144.1 NZ_CP071769:c5342-5040 [Acinetobacter towneri]
MYSIYTTEVFDDWFTKLKDLQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T196888 NZ_CP095505:3532223-3532510 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT196888 WP_000985610.1 NZ_CP071769:c5039-4758 [Acinetobacter towneri]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT196888 NZ_CP095505:3532497-3532799 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCATCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References