Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 112569..113153 Replicon plasmid pGX3-1
Accession NZ_CP071767
Organism Acinetobacter towneri strain GX3

Toxin (Protein)


Gene name PumA Uniprot ID N8Q7V3
Locus tag J4G44_RS13055 Protein ID WP_000286964.1
Coordinates 112569..112871 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4G44_RS13060 Protein ID WP_000985609.1
Coordinates 112872..113153 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G44_RS13025 (J4G44_13025) 108689..109057 - 369 Protein_102 IS1-like element ISAba3 family transposase -
J4G44_RS13030 (J4G44_13030) 109138..109980 + 843 WP_002002480.1 carbapenem-hydrolyzing class D beta-lactamase OXA-58 -
J4G44_RS13035 (J4G44_13035) 110071..110777 + 707 Protein_104 IS1 family transposase -
J4G44_RS13040 (J4G44_13040) 110951..111328 + 378 Protein_105 AraC family ligand binding domain-containing protein -
J4G44_RS13595 111307..111500 + 194 Protein_106 BrnT family toxin -
J4G44_RS13045 (J4G44_13045) 111487..111801 + 315 WP_004728120.1 BrnA antitoxin family protein -
J4G44_RS13050 (J4G44_13050) 111890..112420 - 531 WP_000172759.1 hypothetical protein -
J4G44_RS13055 (J4G44_13055) 112569..112871 + 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G44_RS13060 (J4G44_13060) 112872..113153 + 282 WP_000985609.1 putative addiction module antidote protein Antitoxin
J4G44_RS13065 (J4G44_13065) 113244..114569 - 1326 WP_096902756.1 ISNCY family transposase -
J4G44_RS13070 (J4G44_13070) 114720..115139 - 420 WP_001180106.1 SMI1/KNR4 family protein -
J4G44_RS13075 (J4G44_13075) 115279..115599 + 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4G44_RS13080 (J4G44_13080) 115592..115864 + 273 WP_000369781.1 NadS family protein -
J4G44_RS13085 (J4G44_13085) 115975..116934 - 960 WP_180006246.1 IS30 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / tet(X3) / sul2 / dfrA20 / floR / blaOXA-58 / msr(E) / mph(E) - 1..148166 148166
- inside IScluster/Tn blaOXA-58 / msr(E) / mph(E) - 107217..119740 12523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-90)

Antitoxin

(4-91)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11573.07 Da        Isoelectric Point: 4.6838

>T196885 WP_000286964.1 NZ_CP071767:112569-112871 [Acinetobacter towneri]
MYSIYTTEVFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T196885 NZ_CP095505:c3161387-3161010 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACCCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT196885 WP_000985609.1 NZ_CP071767:112872-113153 [Acinetobacter towneri]
MAIKLRKWDSAEHLKTEDDMQAYLQACIEESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT196885 NZ_CP095505:c3161845-3161477 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCACGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A8TV94


Antitoxin

Source ID Structure

References