Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 96527..97111 Replicon plasmid pGX3-1
Accession NZ_CP071767
Organism Acinetobacter towneri strain GX3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J4G44_RS12975 Protein ID WP_154320144.1
Coordinates 96527..96829 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag J4G44_RS12980 Protein ID WP_000985610.1
Coordinates 96830..97111 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G44_RS12950 (J4G44_12950) 92147..93229 + 1083 WP_004969299.1 hypothetical protein -
J4G44_RS13620 93323..93448 - 126 WP_004969301.1 hypothetical protein -
J4G44_RS12955 (J4G44_12955) 93665..93961 + 297 WP_004647749.1 type II toxin-antitoxin system RelE/ParE family toxin -
J4G44_RS12960 (J4G44_12960) 93963..94253 + 291 WP_004969304.1 putative addiction module antidote protein -
J4G44_RS12965 (J4G44_12965) 94364..95818 - 1455 WP_026438532.1 SulP family inorganic anion transporter -
J4G44_RS12970 (J4G44_12970) 96068..96277 - 210 WP_004976362.1 hypothetical protein -
J4G44_RS12975 (J4G44_12975) 96527..96829 + 303 WP_154320144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G44_RS12980 (J4G44_12980) 96830..97111 + 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
J4G44_RS12985 (J4G44_12985) 97242..98060 + 819 WP_179989168.1 AraC family transcriptional regulator -
J4G44_RS12990 (J4G44_12990) 98088..98684 - 597 WP_074163998.1 LysE family transporter -
J4G44_RS12995 (J4G44_12995) 99111..100274 + 1164 WP_032073150.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / tet(X3) / sul2 / dfrA20 / floR / blaOXA-58 / msr(E) / mph(E) - 1..148166 148166


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11558.10 Da        Isoelectric Point: 4.6838

>T196884 WP_154320144.1 NZ_CP071767:96527-96829 [Acinetobacter towneri]
MYSIYTTEVFDDWFTKLKDLQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T196884 NZ_CP095505:3149613-3149786 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT196884 WP_000985610.1 NZ_CP071767:96830-97111 [Acinetobacter towneri]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT196884 NZ_CP095505:3149289-3149585 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References