Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2274045..2274573 Replicon chromosome
Accession NZ_CP071766
Organism Acinetobacter towneri strain GX3

Toxin (Protein)


Gene name relE Uniprot ID N9CJV8
Locus tag J4G44_RS10995 Protein ID WP_004970510.1
Coordinates 2274280..2274573 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4G44_RS10990 Protein ID WP_104852301.1
Coordinates 2274045..2274290 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4G44_RS10965 (J4G44_10965) 2269123..2269551 - 429 WP_004972647.1 YraN family protein -
J4G44_RS10970 (J4G44_10970) 2269757..2270599 + 843 WP_179991266.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
J4G44_RS10975 (J4G44_10975) 2270792..2271040 - 249 WP_207973652.1 hypothetical protein -
J4G44_RS10980 (J4G44_10980) 2271217..2272467 - 1251 WP_207973653.1 FAD-dependent monooxygenase -
J4G44_RS10985 (J4G44_10985) 2272464..2273672 - 1209 WP_179990342.1 2-octaprenyl-6-methoxyphenyl hydroxylase -
J4G44_RS10990 (J4G44_10990) 2274045..2274290 + 246 WP_104852301.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J4G44_RS10995 (J4G44_10995) 2274280..2274573 + 294 WP_004970510.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4G44_RS11000 (J4G44_11000) 2274653..2275987 - 1335 WP_154320488.1 Xaa-Pro aminopeptidase -
J4G44_RS11005 (J4G44_11005) 2276082..2276720 - 639 WP_179996074.1 UPF0149 family protein -
J4G44_RS11010 (J4G44_11010) 2276785..2277336 + 552 WP_207973654.1 hypothetical protein -
J4G44_RS11015 (J4G44_11015) 2277338..2277622 + 285 WP_004970518.1 cell division protein ZapA -
J4G44_RS11025 (J4G44_11025) 2277963..2278364 - 402 WP_004970519.1 helix-turn-helix domain-containing protein -
J4G44_RS11030 (J4G44_11030) 2278366..2278656 - 291 WP_019836372.1 type II toxin-antitoxin system HigB family toxin -
J4G44_RS11035 (J4G44_11035) 2278728..2279222 - 495 WP_004970523.1 flavin reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-74)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11279.44 Da        Isoelectric Point: 10.3743

>T196882 WP_004970510.1 NZ_CP071766:2274280-2274573 [Acinetobacter towneri]
MTYNLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLIYQVKDDQVVILLITVG
KRADNIVYDEAKKRIKD

Download         Length: 294 bp

>T196882 NZ_CP095505:c2443921-2443814 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCAGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9247.60 Da        Isoelectric Point: 4.3885

>AT196882 WP_104852301.1 NZ_CP071766:2274045-2274290 [Acinetobacter towneri]
MATVNFRVDEALKEKSYSILKEQGISPTDFFTNILEYVATTGKLPVHKALLSEEDAELLALVRKRMNDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT196882 NZ_CP095505:2443969-2444035 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9CJV8

Antitoxin

Source ID Structure

References