Detailed information of TA system TA196881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 1902881..1903464
• Replicon: chromosome
• Accession: NZ_CP071766
• Organism: Acinetobacter towneri strain GX3

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: J4G44_RS09250
• Protein ID: WP_096900853.1
• Coordinates: 1902881..1903216 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: N9CN57
• Locus tag: J4G44_RS09255
• Protein ID: WP_004973383.1
• Coordinates: 1903216..1903464 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4G44_RS09230 (J4G44_09230)	1898138..1898443	+	306	WP_154320717.1	hypothetical protein	-
J4G44_RS09235 (J4G44_09235)	1898587..1899960	+	1374	WP_004973390.1	AarF/ABC1/UbiB kinase family protein	-
J4G44_RS09240 (J4G44_09240)	1900230..1901540	+	1311	WP_004973388.1	acyl-CoA dehydrogenase family protein	-
J4G44_RS09245 (J4G44_09245)	1901592..1902791	+	1200	WP_207973585.1	acyl-CoA dehydrogenase family protein	-
J4G44_RS09250 (J4G44_09250)	1902881..1903216	-	336	WP_096900853.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
J4G44_RS09255 (J4G44_09255)	1903216..1903464	-	249	WP_004973383.1	hypothetical protein	Antitoxin
J4G44_RS09260 (J4G44_09260)	1903641..1904846	-	1206	WP_004973378.1	alkane 1-monooxygenase	-
J4G44_RS09265 (J4G44_09265)	1905013..1905966	+	954	WP_179990757.1	AraC family transcriptional regulator	-
J4G44_RS09270 (J4G44_09270)	1905972..1907147	-	1176	WP_004973375.1	lipid-A-disaccharide synthase	-
J4G44_RS09275 (J4G44_09275)	1907374..1908261	+	888	WP_004973373.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-101)

Antitoxin

• Antitoxin PemI-like (3-80)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12262.07 Da
• Isoelectric Point: 6.2162

>T196881 WP_096900853.1 NZ_CP071766:c1903216-1902881 [Acinetobacter towneri]
MNQGDIYLISLDPTLGHEQQGKRPVFVISPKSFNLITKMPIVLPITSGGNFARNMGFAVELIGGKTTGIVRCDQSRALDF
EARHARFLESSHADVLDEVLARYIAIFSPED

Nucleotide

• Length: 336 bp

>T196881 NZ_CP095505:c1693625-1693218 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8866.38 Da
• Isoelectric Point: 7.3181

>AT196881 WP_004973383.1 NZ_CP071766:c1903464-1903216 [Acinetobacter towneri]
MIHTNLRKVGGSVMLAVPPTLLKSLGLDAGKEVSLSIVNGKLVVEPKAKPSYKLADLLQEHQALALEQDAWHDVKAVGRE
EI

Nucleotide

• Length: 249 bp

>AT196881 NZ_CP095505:c1693872-1693606 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: N9CN57