Detailed information of TA system TA196880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1818995..1819569
• Replicon: chromosome
• Accession: NZ_CP071766
• Organism: Acinetobacter towneri strain GX3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: N9B925
• Locus tag: J4G44_RS08815
• Protein ID: WP_004973562.1
• Coordinates: 1819381..1819569 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9B7X5
• Locus tag: J4G44_RS08810
• Protein ID: WP_004973564.1
• Coordinates: 1818995..1819378 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4G44_RS08790 (J4G44_08790)	1814520..1815641	-	1122	WP_179994188.1	phosphotransferase family protein	-
J4G44_RS08795 (J4G44_08795)	1815772..1817013	-	1242	WP_207973576.1	acyl-CoA dehydrogenase family protein	-
J4G44_RS08800 (J4G44_08800)	1817106..1818023	+	918	WP_104851971.1	LysR family transcriptional regulator	-
J4G44_RS08805 (J4G44_08805)	1818128..1818619	-	492	WP_004973565.1	hypothetical protein	-
J4G44_RS08810 (J4G44_08810)	1818995..1819378	-	384	WP_004973564.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J4G44_RS08815 (J4G44_08815)	1819381..1819569	-	189	WP_004973562.1	type II toxin-antitoxin system HicA family toxin	Toxin
J4G44_RS08820 (J4G44_08820)	1819702..1821096	-	1395	WP_167846017.1	class II fumarate hydratase	-
J4G44_RS08825 (J4G44_08825)	1821270..1822274	-	1005	WP_096902815.1	SDR family NAD(P)-dependent oxidoreductase	-
J4G44_RS08830 (J4G44_08830)	1822335..1822703	+	369	WP_154320742.1	sulfurtransferase complex subunit TusD	-
J4G44_RS08835 (J4G44_08835)	1822747..1823097	+	351	WP_180158927.1	hypothetical protein	-
J4G44_RS08840 (J4G44_08840)	1823163..1823447	+	285	WP_004973553.1	DsrH/TusB family sulfur metabolism protein	-
J4G44_RS08845 (J4G44_08845)	1823506..1823817	+	312	WP_026438386.1	TusE/DsrC/DsvC family sulfur relay protein	-
J4G44_RS08850 (J4G44_08850)	1823849..1824337	-	489	WP_004973550.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7350.46 Da
• Isoelectric Point: 10.2954

>T196880 WP_004973562.1 NZ_CP071766:c1819569-1819381 [Acinetobacter towneri]
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKPGHVVVPHPRKDMPIGTLRNIYKQAGWEWR

Nucleotide

• Length: 189 bp

>T196880 NZ_CP071766:c1819569-1819381 [Acinetobacter towneri]
ATGAACAGCAAAGACATTATTAAGCGTCTTGAGCAGGAAGGCTGGTACAAAGTGGGTGGTAAAGGCGACCATGAAAAGTA
TAAGCATCCTGAAAAGCCTGGACATGTTGTGGTACCACATCCACGTAAAGATATGCCAATAGGAACTCTACGCAATATAT
ATAAACAGGCTGGTTGGGAGTGGAGGTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14346.19 Da
• Isoelectric Point: 4.3695

>AT196880 WP_004973564.1 NZ_CP071766:c1819378-1818995 [Acinetobacter towneri]
MLYPVYVHKDEDSAYGLTFPDFDGCFSAADEMQDIQRMAQEAVEVHFDGEDIPLPEPSSPEQWLGDERFEGGFWLLVDID
TTKVNTKSIRINISMPEALVKRIDAVAKKQHLSRSAFLAKSAEMALH

Nucleotide

• Length: 384 bp

>AT196880 NZ_CP071766:c1819378-1818995 [Acinetobacter towneri]
ATGTTATATCCAGTATATGTTCACAAAGATGAAGATAGCGCATACGGTTTAACCTTTCCTGACTTTGATGGATGCTTTAG
CGCAGCAGATGAGATGCAAGATATTCAGCGCATGGCACAGGAAGCGGTTGAAGTTCACTTTGATGGTGAAGATATTCCGT
TACCAGAACCATCAAGCCCAGAGCAATGGTTAGGTGATGAGCGATTTGAGGGGGGTTTTTGGTTGTTAGTTGATATTGAT
ACAACAAAAGTAAATACAAAGTCTATTCGTATTAATATCAGCATGCCAGAAGCTTTAGTGAAACGTATTGATGCTGTTGC
AAAAAAACAACATTTAAGCCGTTCGGCATTCTTAGCTAAAAGCGCGGAAATGGCGTTGCATTAA

Structures

Toxin

• AlphaFold DB: N9B925

Antitoxin

• AlphaFold DB: N9B7X5