Detailed information of TA system TA196877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 214823..215403
• Replicon: chromosome
• Accession: NZ_CP071766
• Organism: Acinetobacter towneri strain GX3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: J4G44_RS01035
• Protein ID: WP_207973761.1
• Coordinates: 215155..215403 (-)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9B896
• Locus tag: J4G44_RS01030
• Protein ID: WP_004974672.1
• Coordinates: 214823..215158 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4G44_RS01020 (J4G44_01020)	210991..211863	-	873	WP_004974677.1	acyl-CoA thioesterase II	-
J4G44_RS01025 (J4G44_01025)	212168..214732	+	2565	WP_004974675.1	glycerol-3-phosphate 1-O-acyltransferase PlsB	-
J4G44_RS01030 (J4G44_01030)	214823..215158	-	336	WP_004974672.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J4G44_RS01035 (J4G44_01035)	215155..215403	-	249	WP_207973761.1	type II toxin-antitoxin system HicA family toxin	Toxin
J4G44_RS01040 (J4G44_01040)	215502..216281	-	780	WP_004974669.1	NAD(P)H-binding protein	-
J4G44_RS01045 (J4G44_01045)	216318..218363	+	2046	WP_180044029.1	ATP-dependent DNA helicase RecG	-
J4G44_RS01050 (J4G44_01050)	218382..219017	+	636	WP_154320297.1	phosphoribosyltransferase family protein	-
J4G44_RS01055 (J4G44_01055)	219092..219502	-	411	WP_004974664.1	NUDIX domain-containing protein	-
J4G44_RS01060 (J4G44_01060)	219504..220106	-	603	WP_026438479.1	TIGR00730 family Rossman fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-78)

Antitoxin

• Uncharacterised protein family HicB (54-102)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9388.02 Da
• Isoelectric Point: 10.2183

>T196877 WP_207973761.1 NZ_CP071766:c215403-215155 [Acinetobacter towneri]
MGKTEKLLDKIGNSKNTFPYKDLVVLLSQLGYEKFEMAGSRVRFYNLKTEHMILLHRPHPENEIKGGALKAVKQALKQEG
FL

Nucleotide

• Length: 249 bp

>T196877 NZ_CP095505:c648197-647943 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCACTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12488.22 Da
• Isoelectric Point: 4.5942

>AT196877 WP_004974672.1 NZ_CP071766:c215158-214823 [Acinetobacter towneri]
MSYFKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKTLEQAFQESVDGYLDSCAELGKKPDQPFKGTFNVRISPE
LHRKAVLASEESSLNAFVSDAIQEKLMRLGV

Nucleotide

• Length: 336 bp

>AT196877 NZ_CP095505:c648445-648194 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: N9B896