196875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3957013..3957601 Replicon chromosome
Accession NZ_CP071763
Organism Acinetobacter baumannii strain Cl415

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag OMLMMPMB_RS18995 Protein ID WP_000438826.1
Coordinates 3957013..3957300 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag OMLMMPMB_RS19000 Protein ID WP_001983304.1
Coordinates 3957287..3957601 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMLMMPMB_RS18960 (OMLMMPMB_03816) 3952695..3953015 - 321 WP_000251652.1 membrane protein insertion efficiency factor YidD -
OMLMMPMB_RS18965 (OMLMMPMB_03817) 3953026..3953418 - 393 WP_001240374.1 ribonuclease P protein component -
OMLMMPMB_RS18970 (OMLMMPMB_03818) 3953448..3953582 - 135 WP_000831329.1 50S ribosomal protein L34 -
OMLMMPMB_RS18975 (OMLMMPMB_03819) 3954252..3955202 + 951 WP_001205343.1 replication initiation protein RepM -
OMLMMPMB_RS18980 (OMLMMPMB_03820) 3955195..3955770 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
OMLMMPMB_RS18985 (OMLMMPMB_03821) 3955790..3955933 + 144 WP_001125246.1 hypothetical protein -
OMLMMPMB_RS18990 (OMLMMPMB_03822) 3956122..3956640 - 519 WP_000447193.1 tetratricopeptide repeat protein -
OMLMMPMB_RS18995 (OMLMMPMB_03823) 3957013..3957300 + 288 WP_000438826.1 BrnT family toxin Toxin
OMLMMPMB_RS19000 (OMLMMPMB_03824) 3957287..3957601 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
OMLMMPMB_RS19005 (OMLMMPMB_03825) 3957729..3960140 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
OMLMMPMB_RS19010 (OMLMMPMB_03826) 3960445..3960906 + 462 WP_000761346.1 DIP1984 family protein -
OMLMMPMB_RS19015 3961229..3961402 - 174 WP_001282484.1 hypothetical protein -
OMLMMPMB_RS19020 (OMLMMPMB_03827) 3961402..3961773 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3955790..3964816 9026


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T196875 WP_000438826.1 NZ_CP071763:3957013-3957300 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T196875 NZ_CP095505:c43702-42380 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGAGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAATGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGGGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT196875 WP_001983304.1 NZ_CP071763:3957287-3957601 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT196875 NZ_CP095505:c43968-43702 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTAACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References