Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1216147..1216826 | Replicon | chromosome |
| Accession | NZ_CP071763 | ||
| Organism | Acinetobacter baumannii strain Cl415 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | S3TWT7 |
| Locus tag | OMLMMPMB_RS05780 | Protein ID | WP_000838146.1 |
| Coordinates | 1216147..1216329 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9L2H6 |
| Locus tag | OMLMMPMB_RS05785 | Protein ID | WP_000966688.1 |
| Coordinates | 1216422..1216826 (+) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OMLMMPMB_RS05745 (OMLMMPMB_01153) | 1211552..1211956 | + | 405 | WP_000248222.1 | hypothetical protein | - |
| OMLMMPMB_RS05750 (OMLMMPMB_01154) | 1211928..1212296 | + | 369 | WP_000539746.1 | hypothetical protein | - |
| OMLMMPMB_RS05755 (OMLMMPMB_01155) | 1212298..1212696 | + | 399 | WP_000178914.1 | phage tail terminator-like protein | - |
| OMLMMPMB_RS05760 (OMLMMPMB_01156) | 1212765..1213118 | + | 354 | WP_118938922.1 | hypothetical protein | - |
| OMLMMPMB_RS05765 (OMLMMPMB_01157) | 1213118..1214266 | + | 1149 | WP_107309648.1 | phage tail protein | - |
| OMLMMPMB_RS05770 (OMLMMPMB_01158) | 1214319..1215236 | + | 918 | WP_024435783.1 | phage tail tube protein | - |
| OMLMMPMB_RS05775 (OMLMMPMB_01159) | 1215306..1215821 | + | 516 | WP_032063623.1 | hypothetical protein | - |
| OMLMMPMB_RS05780 (OMLMMPMB_01160) | 1216147..1216329 | + | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| OMLMMPMB_RS05785 (OMLMMPMB_01161) | 1216422..1216826 | + | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| OMLMMPMB_RS05790 (OMLMMPMB_01162) | 1216926..1217450 | + | 525 | WP_000721574.1 | DUF4468 domain-containing protein | - |
| OMLMMPMB_RS05795 (OMLMMPMB_01163) | 1217515..1217898 | + | 384 | WP_000725052.1 | hypothetical protein | - |
| OMLMMPMB_RS05800 (OMLMMPMB_01164) | 1217960..1218706 | + | 747 | WP_000599537.1 | hypothetical protein | - |
| OMLMMPMB_RS05805 (OMLMMPMB_01165) | 1218792..1219283 | + | 492 | WP_000755583.1 | DUF4468 domain-containing protein | - |
| OMLMMPMB_RS05810 (OMLMMPMB_01166) | 1219326..1219592 | - | 267 | WP_000774879.1 | hypothetical protein | - |
| OMLMMPMB_RS05815 (OMLMMPMB_01167) | 1219742..1220671 | + | 930 | WP_057078076.1 | ORF6N domain-containing protein | - |
| OMLMMPMB_RS05820 (OMLMMPMB_01168) | 1220807..1221316 | + | 510 | WP_057078075.1 | Rha family transcriptional regulator | - |
| OMLMMPMB_RS05825 (OMLMMPMB_01169) | 1221440..1221787 | + | 348 | WP_057078074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | blaOXA-23 | - | 1185579..1251856 | 66277 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T196874 WP_000838146.1 NZ_CP071763:1216147-1216329 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T196874 NZ_CP095505:c6783-6505 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT196874 WP_000966688.1 NZ_CP071763:1216422-1216826 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT196874 NZ_CP095505:c6505-6221 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|