Detailed information of TA system TA196873

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 447992..448645
• Replicon: chromosome
• Accession: NZ_CP071763
• Organism: Acinetobacter baumannii strain Cl415

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: OMLMMPMB_RS02180
• Protein ID: WP_000607077.1
• Coordinates: 448256..448645 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: OMLMMPMB_RS02175
• Protein ID: WP_001288210.1
• Coordinates: 447992..448249 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OMLMMPMB_RS02155 (OMLMMPMB_00428)	443508..444515	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
OMLMMPMB_RS02160 (OMLMMPMB_00429)	444534..444911	+	378	WP_064894046.1	50S ribosomal protein L17	-
OMLMMPMB_RS02165 (OMLMMPMB_00430)	445093..446583	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
OMLMMPMB_RS02170 (OMLMMPMB_00431)	446632..447804	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
OMLMMPMB_RS02175 (OMLMMPMB_00432)	447992..448249	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
OMLMMPMB_RS02180 (OMLMMPMB_00433)	448256..448645	+	390	WP_000607077.1	membrane protein	Toxin
OMLMMPMB_RS02185 (OMLMMPMB_00435)	449415..450500	+	1086	WP_000049106.1	hypothetical protein	-
OMLMMPMB_RS02190 (OMLMMPMB_00436)	450578..451144	+	567	WP_000651538.1	rhombosortase	-
OMLMMPMB_RS02195 (OMLMMPMB_00437)	451332..453527	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T196873 WP_000607077.1 NZ_CP071763:448256-448645 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T196873 NZ_CP095504:c47865-47560 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT196873 WP_001288210.1 NZ_CP071763:447992-448249 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT196873 NZ_CP095504:c48085-47867 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7