Detailed information of TA system TA196870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 961492..963245
• Replicon: chromosome
• Accession: NZ_CP071762
• Organism: Burkholderia pseudomallei strain VBP23831

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q63JY0
• Locus tag: J3L14_RS21870
• Protein ID: WP_004188815.1
• Coordinates: 961893..963245 (+)
• Length: 451 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J3L14_RS21865
• Protein ID: WP_207877825.1
• Coordinates: 961492..961896 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3L14_RS21855 (J3L14_21855)	958030..960426	-	2397	WP_045588572.1	cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB	-
J3L14_RS21860 (J3L14_21860)	960891..961154	+	264	WP_004199789.1	hypothetical protein	-
J3L14_RS21865 (J3L14_21865)	961492..961896	+	405	WP_207877825.1	helix-turn-helix transcriptional regulator	Antitoxin
J3L14_RS21870 (J3L14_21870)	961893..963245	+	1353	WP_004188815.1	type II toxin-antitoxin system HipA family toxin	Toxin
J3L14_RS21875 (J3L14_21875)	963424..963876	-	453	WP_004198842.1	hypothetical protein	-
J3L14_RS21880 (J3L14_21880)	963977..964123	-	147	WP_004199790.1	hypothetical protein	-
J3L14_RS21885 (J3L14_21885)	964279..965193	-	915	WP_004545706.1	LysR family transcriptional regulator	-
J3L14_RS21890 (J3L14_21890)	965360..966313	+	954	WP_004187785.1	agmatinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (158-408)

Antitoxin

• Cro/C1-type helix-turn-helix domain (22-71)

Sequences

Toxin

Protein

• Length: 451 a.a.
• Molecular weight: 49848.83 Da
• Isoelectric Point: 9.6807

>T196870 WP_004188815.1 NZ_CP071762:961893-963245 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Nucleotide

• Length: 1353 bp

>T196870 NZ_CP095498:186830-187231 [Burkholderia cepacia]
ATGGCGCGCTACATGCTCGACACCAACATGTGCATCTACCTGATGAAGAATCAGCCGGAACAGGTCGCGAGACGATTTGC
GCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATTACCTATGCCGAGCTCGAGTACGGCGTGACCGTGTGTGTACGTC
CGGCCCGGGAGCGCAGCAATCTTGCCGCGCTGATCGAGGATATCCCGGTTGCGCCGTTCGACGCGCCGGCCGCGCAAGCG
TACGGCCCTGTCCGCGAAGCGACCCGCGATCGGAAGAAGGATCATCTCGACAAACTGATCGCGGCGCATGCGGTGTCGCT
CGACGTCGTGCTCGTGACCAACAACGAGCGGGATTTCGCGAGCTACCCGGGCGTGCGGCTGGAGAACTGGCTGAGCGACT
AG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14422.78 Da
• Isoelectric Point: 11.7233

>AT196870 WP_207877825.1 NZ_CP071762:961492-961896 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKSEVAKTVANARAGARRAVPPASAPAPSAAGRPPRPARKRAAPKKREDW

Nucleotide

• Length: 405 bp

>AT196870 NZ_CP095498:186594-186830 [Burkholderia cepacia]
ATGCATACCACGAGGGTGTTTCGGAACGGCAACTCACAGGCCGTACGGATTCCGGCGGATCTTGCTTACGAGCGCAGCGA
TATCGAGCTCGAAATCGAACGGATCGGCGACGAAATCCGTATTCGGCCCATGCGGCGGCCGTTGACCGGCGTGCTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAAGGGCGTGGCGACCACGAACAGGCCGACCGCGAGGGCTTGTGA

Structures

Toxin

• AlphaFold DB: A0A3N4FSX2