Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1381259..1381815 Replicon chromosome
Accession NZ_CP071761
Organism Burkholderia pseudomallei strain VBP23831

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag J3L14_RS06560 Protein ID WP_229655145.1
Coordinates 1381564..1381815 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J3L14_RS06555 Protein ID WP_038780841.1
Coordinates 1381259..1381537 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3L14_RS06535 (J3L14_06535) 1377152..1378048 - 897 WP_122781805.1 hypothetical protein -
J3L14_RS06540 (J3L14_06540) 1378129..1378386 - 258 WP_076927500.1 hypothetical protein -
J3L14_RS06545 (J3L14_06545) 1378875..1379144 + 270 WP_183159590.1 plasmid mobilization protein MobA -
J3L14_RS06550 (J3L14_06550) 1379147..1381156 + 2010 WP_223872105.1 relaxase/mobilization nuclease domain-containing protein -
J3L14_RS06555 (J3L14_06555) 1381259..1381537 + 279 WP_038780841.1 CopG family ribbon-helix-helix protein Antitoxin
J3L14_RS06560 (J3L14_06560) 1381564..1381815 + 252 WP_229655145.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3L14_RS06565 (J3L14_06565) 1381818..1382120 + 303 WP_038780836.1 hypothetical protein -
J3L14_RS32470 1382113..1382241 + 129 WP_256704163.1 hypothetical protein -
J3L14_RS06570 (J3L14_06570) 1382321..1382572 + 252 WP_198046342.1 hypothetical protein -
J3L14_RS06575 (J3L14_06575) 1382714..1385995 + 3282 WP_198046341.1 VPA1262 family protein -
J3L14_RS06580 (J3L14_06580) 1386029..1386550 - 522 WP_038780832.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1368968..1388121 19153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-81)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9556.78 Da        Isoelectric Point: 9.5559

>T196869 WP_229655145.1 NZ_CP071761:1381564-1381815 [Burkholderia pseudomallei]
MQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEQYREWPIDFGDSGYVARYRFDGDAVTILAVRHQKE
AGY

Download         Length: 252 bp

>T196869 NZ_CP095497:2727622-2728203 [Burkholderia cepacia]
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGAATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGTTGACCGCGCCGCTCGATCC
GGTGCAGCGCGACGAAATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCAGCAATCCACCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAGCGCCGGATCGA
CGCGGGCGGGCAGCACGCGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10853.13 Da        Isoelectric Point: 4.8052

>AT196869 WP_038780841.1 NZ_CP071761:1381259-1381537 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREVLNQDTLKAWDEFQETGLHATAEEVDKWLASWG
TENELPPPECHK

Download         Length: 279 bp

>AT196869 NZ_CP095497:2726982-2727539 [Burkholderia cepacia]
ATGTCTGCCTCACCGCTACACGCACCACCGCTCGGCCCGCAGCTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAGCAGAG
CCACGCGGCGGAGCTGTTCGGCGTGGCGCAATCGACGATCTCACGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGACG
AACGCGCGACGGCCGAACGGCTGCTCGCCGCGCACCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATCCATCTCGTGTGCGACCTCACGCACCGGCTGCTCGCCTGTTCGCCTGCGCGAGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGCTGTCGGACGGATCGGCCGCGCGGCTCGTGGAAACGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References