Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
| Location | 1381259..1381815 | Replicon | chromosome |
| Accession | NZ_CP071761 | ||
| Organism | Burkholderia pseudomallei strain VBP23831 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | J3L14_RS06560 | Protein ID | WP_229655145.1 |
| Coordinates | 1381564..1381815 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | J3L14_RS06555 | Protein ID | WP_038780841.1 |
| Coordinates | 1381259..1381537 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3L14_RS06535 (J3L14_06535) | 1377152..1378048 | - | 897 | WP_122781805.1 | hypothetical protein | - |
| J3L14_RS06540 (J3L14_06540) | 1378129..1378386 | - | 258 | WP_076927500.1 | hypothetical protein | - |
| J3L14_RS06545 (J3L14_06545) | 1378875..1379144 | + | 270 | WP_183159590.1 | plasmid mobilization protein MobA | - |
| J3L14_RS06550 (J3L14_06550) | 1379147..1381156 | + | 2010 | WP_223872105.1 | relaxase/mobilization nuclease domain-containing protein | - |
| J3L14_RS06555 (J3L14_06555) | 1381259..1381537 | + | 279 | WP_038780841.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| J3L14_RS06560 (J3L14_06560) | 1381564..1381815 | + | 252 | WP_229655145.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J3L14_RS06565 (J3L14_06565) | 1381818..1382120 | + | 303 | WP_038780836.1 | hypothetical protein | - |
| J3L14_RS32470 | 1382113..1382241 | + | 129 | WP_256704163.1 | hypothetical protein | - |
| J3L14_RS06570 (J3L14_06570) | 1382321..1382572 | + | 252 | WP_198046342.1 | hypothetical protein | - |
| J3L14_RS06575 (J3L14_06575) | 1382714..1385995 | + | 3282 | WP_198046341.1 | VPA1262 family protein | - |
| J3L14_RS06580 (J3L14_06580) | 1386029..1386550 | - | 522 | WP_038780832.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1368968..1388121 | 19153 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9556.78 Da Isoelectric Point: 9.5559
>T196869 WP_229655145.1 NZ_CP071761:1381564-1381815 [Burkholderia pseudomallei]
MQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEQYREWPIDFGDSGYVARYRFDGDAVTILAVRHQKE
AGY
MQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEQYREWPIDFGDSGYVARYRFDGDAVTILAVRHQKE
AGY
Download Length: 252 bp
>T196869 NZ_CP095497:2727622-2728203 [Burkholderia cepacia]
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGAATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGTTGACCGCGCCGCTCGATCC
GGTGCAGCGCGACGAAATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCAGCAATCCACCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAGCGCCGGATCGA
CGCGGGCGGGCAGCACGCGTAA
ATGAACCCCGATACGATCCACGCGCGGCTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGAATGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACCGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCACTCGTATTCGCCGATGCGC
TGCCCGGCATCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGTTGACCGCGCCGCTCGATCC
GGTGCAGCGCGACGAAATCGTCGCACTGTGGGATGAATACGAAGCGGCCGCGTCGCCGGAAGCGCGCGCGGCGAAAGCGT
TCGACAAGCTGGAGACGATCCTGCAGCACACCCAGGGCAGCAATCCACCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGCCGCTATACCGACGCCGCACCGCTGTTCAGCGCGATCCGCGACATCGTCGACGCCGACACGCAGCGCCGGATCGA
CGCGGGCGGGCAGCACGCGTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10853.13 Da Isoelectric Point: 4.8052
>AT196869 WP_038780841.1 NZ_CP071761:1381259-1381537 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREVLNQDTLKAWDEFQETGLHATAEEVDKWLASWG
TENELPPPECHK
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREVLNQDTLKAWDEFQETGLHATAEEVDKWLASWG
TENELPPPECHK
Download Length: 279 bp
>AT196869 NZ_CP095497:2726982-2727539 [Burkholderia cepacia]
ATGTCTGCCTCACCGCTACACGCACCACCGCTCGGCCCGCAGCTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAGCAGAG
CCACGCGGCGGAGCTGTTCGGCGTGGCGCAATCGACGATCTCACGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGACG
AACGCGCGACGGCCGAACGGCTGCTCGCCGCGCACCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATCCATCTCGTGTGCGACCTCACGCACCGGCTGCTCGCCTGTTCGCCTGCGCGAGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGCTGTCGGACGGATCGGCCGCGCGGCTCGTGGAAACGCTGTAA
ATGTCTGCCTCACCGCTACACGCACCACCGCTCGGCCCGCAGCTCAAGCGCTGGCGTGCGCTGCACCGCGTGAAGCAGAG
CCACGCGGCGGAGCTGTTCGGCGTGGCGCAATCGACGATCTCACGCTGGGAAGCCGGCCTGCAACAGATGTCGCCCGACG
AACGCGCGACGGCCGAACGGCTGCTCGCCGCGCACCTCGATTCCGCGGGCGATCACGCGCTTGCGCGGCTCGTCGCGGGC
AGCGCGGGCCGCATCCATCTCGTGTGCGACCTCACGCACCGGCTGCTCGCCTGTTCGCCTGCGCGAGCAGCCGAATTCTC
GCAACCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ATACGCTCGGCTGGCATGATCGCGCGGGGCCGCCGAGCGTCGAATTCGATACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCTGTGCCGGTGGACACGGATGACGCTGTCGGACGGATCGGCCGCGCGGCTCGTGGAAACGCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|