Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 1265158..1265680 | Replicon | chromosome |
Accession | NZ_CP071761 | ||
Organism | Burkholderia pseudomallei strain VBP23831 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | J3L14_RS06040 | Protein ID | WP_151271055.1 |
Coordinates | 1265387..1265680 (+) | Length | 98 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | J3L14_RS06035 | Protein ID | WP_059468969.1 |
Coordinates | 1265158..1265400 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J3L14_RS05995 (J3L14_05995) | 1260285..1260578 | + | 294 | WP_151271049.1 | phage holin family protein | - |
J3L14_RS06000 (J3L14_06000) | 1260571..1260990 | + | 420 | WP_151271050.1 | glycoside hydrolase family protein | - |
J3L14_RS06005 (J3L14_06005) | 1260987..1261481 | + | 495 | WP_151271051.1 | DUF2514 family protein | - |
J3L14_RS06010 (J3L14_06010) | 1261650..1262438 | + | 789 | WP_059670899.1 | DNA adenine methylase | - |
J3L14_RS06015 (J3L14_06015) | 1262549..1263436 | + | 888 | WP_151271052.1 | hypothetical protein | - |
J3L14_RS06020 (J3L14_06020) | 1263489..1263998 | - | 510 | WP_151271053.1 | hypothetical protein | - |
J3L14_RS06025 (J3L14_06025) | 1264199..1264855 | + | 657 | WP_151271054.1 | SOS response-associated peptidase family protein | - |
J3L14_RS06030 (J3L14_06030) | 1264989..1265168 | - | 180 | WP_207877143.1 | hypothetical protein | - |
J3L14_RS06035 (J3L14_06035) | 1265158..1265400 | + | 243 | WP_059468969.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
J3L14_RS06040 (J3L14_06040) | 1265387..1265680 | + | 294 | WP_151271055.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
J3L14_RS06045 (J3L14_06045) | 1266928..1267440 | - | 513 | WP_004193834.1 | GAF domain-containing protein | - |
J3L14_RS06050 (J3L14_06050) | 1267607..1268515 | - | 909 | WP_004197652.1 | LysR family transcriptional regulator | - |
J3L14_RS06055 (J3L14_06055) | 1268642..1269508 | + | 867 | WP_004191946.1 | pirin family protein | - |
J3L14_RS06060 (J3L14_06060) | 1269742..1270245 | + | 504 | WP_004554230.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11150.18 Da Isoelectric Point: 10.3609
>T196868 WP_151271055.1 NZ_CP071761:1265387-1265680 [Burkholderia pseudomallei]
MKTYDLKFVVDALKEWEKLDKTVREQFKKKLAERLKNPHVPSAKLSGDLDHCYKIKLLALGYRLVYRVDDTVITVTVISV
GKRERSAVYAAAVARLK
MKTYDLKFVVDALKEWEKLDKTVREQFKKKLAERLKNPHVPSAKLSGDLDHCYKIKLLALGYRLVYRVDDTVITVTVISV
GKRERSAVYAAAVARLK
Download Length: 294 bp
>T196868 NZ_CP095497:c2566623-2566204 [Burkholderia cepacia]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGACGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGATCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCATTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACGCGCTCGTGCCGCAGGTGTCGCAATTGCACCATCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGACGTCACGCCGTTCGAGGCAATGGGGATTCGCGTAA
TCGACCCGTGGGCGCGCTAG
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGACGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGATCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCATTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACGCGCTCGTGCCGCAGGTGTCGCAATTGCACCATCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGACGTCACGCCGTTCGAGGCAATGGGGATTCGCGTAA
TCGACCCGTGGGCGCGCTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8639.89 Da Isoelectric Point: 4.1370
>AT196868 WP_059468969.1 NZ_CP071761:1265158-1265400 [Burkholderia pseudomallei]
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNRPVAYLIPAAEWEAICDRLEDVELAAIVRARLGQEAVSVNLEDL
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNRPVAYLIPAAEWEAICDRLEDVELAAIVRARLGQEAVSVNLEDL
Download Length: 243 bp
>AT196868 NZ_CP095497:c2566859-2566620 [Burkholderia cepacia]
ATGCCGGTGATTACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCGGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGACCCGATGAGCTTCGAATGA
ATGCCGGTGATTACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCGGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGACCCGATGAGCTTCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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