Detailed information of TA system TA196868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1265158..1265680
• Replicon: chromosome
• Accession: NZ_CP071761
• Organism: Burkholderia pseudomallei strain VBP23831

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J3L14_RS06040
• Protein ID: WP_151271055.1
• Coordinates: 1265387..1265680 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J3L14_RS06035
• Protein ID: WP_059468969.1
• Coordinates: 1265158..1265400 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3L14_RS05995 (J3L14_05995)	1260285..1260578	+	294	WP_151271049.1	phage holin family protein	-
J3L14_RS06000 (J3L14_06000)	1260571..1260990	+	420	WP_151271050.1	glycoside hydrolase family protein	-
J3L14_RS06005 (J3L14_06005)	1260987..1261481	+	495	WP_151271051.1	DUF2514 family protein	-
J3L14_RS06010 (J3L14_06010)	1261650..1262438	+	789	WP_059670899.1	DNA adenine methylase	-
J3L14_RS06015 (J3L14_06015)	1262549..1263436	+	888	WP_151271052.1	hypothetical protein	-
J3L14_RS06020 (J3L14_06020)	1263489..1263998	-	510	WP_151271053.1	hypothetical protein	-
J3L14_RS06025 (J3L14_06025)	1264199..1264855	+	657	WP_151271054.1	SOS response-associated peptidase family protein	-
J3L14_RS06030 (J3L14_06030)	1264989..1265168	-	180	WP_207877143.1	hypothetical protein	-
J3L14_RS06035 (J3L14_06035)	1265158..1265400	+	243	WP_059468969.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J3L14_RS06040 (J3L14_06040)	1265387..1265680	+	294	WP_151271055.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J3L14_RS06045 (J3L14_06045)	1266928..1267440	-	513	WP_004193834.1	GAF domain-containing protein	-
J3L14_RS06050 (J3L14_06050)	1267607..1268515	-	909	WP_004197652.1	LysR family transcriptional regulator	-
J3L14_RS06055 (J3L14_06055)	1268642..1269508	+	867	WP_004191946.1	pirin family protein	-
J3L14_RS06060 (J3L14_06060)	1269742..1270245	+	504	WP_004554230.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-76)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11150.18 Da
• Isoelectric Point: 10.3609

>T196868 WP_151271055.1 NZ_CP071761:1265387-1265680 [Burkholderia pseudomallei]
MKTYDLKFVVDALKEWEKLDKTVREQFKKKLAERLKNPHVPSAKLSGDLDHCYKIKLLALGYRLVYRVDDTVITVTVISV
GKRERSAVYAAAVARLK

Nucleotide

• Length: 294 bp

>T196868 NZ_CP095497:c2566623-2566204 [Burkholderia cepacia]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGACGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGATCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCATTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACGCGCTCGTGCCGCAGGTGTCGCAATTGCACCATCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGACGTCACGCCGTTCGAGGCAATGGGGATTCGCGTAA
TCGACCCGTGGGCGCGCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8639.89 Da
• Isoelectric Point: 4.1370

>AT196868 WP_059468969.1 NZ_CP071761:1265158-1265400 [Burkholderia pseudomallei]
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNRPVAYLIPAAEWEAICDRLEDVELAAIVRARLGQEAVSVNLEDL

Nucleotide

• Length: 243 bp

>AT196868 NZ_CP095497:c2566859-2566620 [Burkholderia cepacia]
ATGCCGGTGATTACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCGGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGACCCGATGAGCTTCGAATGA