196868

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1265158..1265680 Replicon chromosome
Accession NZ_CP071761
Organism Burkholderia pseudomallei strain VBP23831

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J3L14_RS06040 Protein ID WP_151271055.1
Coordinates 1265387..1265680 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J3L14_RS06035 Protein ID WP_059468969.1
Coordinates 1265158..1265400 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3L14_RS05995 (J3L14_05995) 1260285..1260578 + 294 WP_151271049.1 phage holin family protein -
J3L14_RS06000 (J3L14_06000) 1260571..1260990 + 420 WP_151271050.1 glycoside hydrolase family protein -
J3L14_RS06005 (J3L14_06005) 1260987..1261481 + 495 WP_151271051.1 DUF2514 family protein -
J3L14_RS06010 (J3L14_06010) 1261650..1262438 + 789 WP_059670899.1 DNA adenine methylase -
J3L14_RS06015 (J3L14_06015) 1262549..1263436 + 888 WP_151271052.1 hypothetical protein -
J3L14_RS06020 (J3L14_06020) 1263489..1263998 - 510 WP_151271053.1 hypothetical protein -
J3L14_RS06025 (J3L14_06025) 1264199..1264855 + 657 WP_151271054.1 SOS response-associated peptidase family protein -
J3L14_RS06030 (J3L14_06030) 1264989..1265168 - 180 WP_207877143.1 hypothetical protein -
J3L14_RS06035 (J3L14_06035) 1265158..1265400 + 243 WP_059468969.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J3L14_RS06040 (J3L14_06040) 1265387..1265680 + 294 WP_151271055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3L14_RS06045 (J3L14_06045) 1266928..1267440 - 513 WP_004193834.1 GAF domain-containing protein -
J3L14_RS06050 (J3L14_06050) 1267607..1268515 - 909 WP_004197652.1 LysR family transcriptional regulator -
J3L14_RS06055 (J3L14_06055) 1268642..1269508 + 867 WP_004191946.1 pirin family protein -
J3L14_RS06060 (J3L14_06060) 1269742..1270245 + 504 WP_004554230.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 11150.18 Da        Isoelectric Point: 10.3609

>T196868 WP_151271055.1 NZ_CP071761:1265387-1265680 [Burkholderia pseudomallei]
MKTYDLKFVVDALKEWEKLDKTVREQFKKKLAERLKNPHVPSAKLSGDLDHCYKIKLLALGYRLVYRVDDTVITVTVISV
GKRERSAVYAAAVARLK

Download         Length: 294 bp

>T196868 NZ_CP095497:c2566623-2566204 [Burkholderia cepacia]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGACGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGATCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCATTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACGCGCTCGTGCCGCAGGTGTCGCAATTGCACCATCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGACGTCACGCCGTTCGAGGCAATGGGGATTCGCGTAA
TCGACCCGTGGGCGCGCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8639.89 Da        Isoelectric Point: 4.1370

>AT196868 WP_059468969.1 NZ_CP071761:1265158-1265400 [Burkholderia pseudomallei]
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNRPVAYLIPAAEWEAICDRLEDVELAAIVRARLGQEAVSVNLEDL

Download         Length: 243 bp

>AT196868 NZ_CP095497:c2566859-2566620 [Burkholderia cepacia]
ATGCCGGTGATTACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCGGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGACCCGATGAGCTTCGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References