196867

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 424949..425604 Replicon chromosome
Accession NZ_CP071761
Organism Burkholderia pseudomallei strain VBP23831

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag J3L14_RS02055 Protein ID WP_006027262.1
Coordinates 425308..425604 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag J3L14_RS02050 Protein ID WP_004202809.1
Coordinates 424949..425305 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3L14_RS02035 (J3L14_02035) 420248..422863 + 2616 WP_186138344.1 S8 family peptidase -
J3L14_RS02040 (J3L14_02040) 423491..423853 + 363 WP_226992848.1 terminase -
J3L14_RS02045 (J3L14_02045) 423850..424905 + 1056 WP_038738790.1 phage portal protein -
J3L14_RS02050 (J3L14_02050) 424949..425305 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
J3L14_RS02055 (J3L14_02055) 425308..425604 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3L14_RS02060 (J3L14_02060) 425909..426379 + 471 WP_243435484.1 AAA family ATPase -
J3L14_RS02065 (J3L14_02065) 426900..427244 + 345 WP_217275508.1 baseplate assembly protein -
J3L14_RS02070 (J3L14_02070) 427237..427632 + 396 Protein_403 phage tail protein I -
J3L14_RS02075 (J3L14_02075) 427632..428151 + 520 Protein_404 site-specific DNA-methyltransferase -
J3L14_RS02080 (J3L14_02080) 428547..429137 + 591 WP_111963042.1 hypothetical protein -
J3L14_RS02085 (J3L14_02085) 429241..429624 - 384 Protein_406 phage virion morphogenesis protein -
J3L14_RS02090 (J3L14_02090) 429708..430493 - 786 WP_004521948.1 type IVB secretion system protein IcmH/DotU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 408176..429606 21430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T196867 WP_006027262.1 NZ_CP071761:c425604-425308 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T196867 NZ_CP095497:c2449016-2448120 [Burkholderia cepacia]
ATGAGTGTCATCGACAAACGTGAGCGCGAGCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCCGGCGCGCAGCACGCGGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACAAGCTCGGCGCGTCGCGGCGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGTGCACCGGCCGAAACACGC
GAATCGCGCCGCGACGCACGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGTTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTTTCCGGCTTTCGCGGTCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGGCATGCCGGTTATGTCGAGGCCCCGGCCGTCTATTCCGCACTGATCGACTCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT196867 WP_004202809.1 NZ_CP071761:c425305-424949 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT196867 NZ_CP095497:c2448123-2447266 [Burkholderia cepacia]
ATGAACGAACCGCTGCAACGACCCGAACCCGAAAACGACAAGGCCGAAGCCAGCTATGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGTGCGCCCGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTTGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTCTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCACTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGCGGCGCTGATCGCCGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTATGAAAGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References