Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 2987335..2989091 | Replicon | chromosome |
| Accession | NZ_CP071760 | ||
| Organism | Burkholderia pseudomallei strain VBP21885 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | C4APV8 |
| Locus tag | J3J51_RS30420 | Protein ID | WP_004195452.1 |
| Coordinates | 2987335..2988240 (+) | Length | 302 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q63LW2 |
| Locus tag | J3J51_RS30425 | Protein ID | WP_004195450.1 |
| Coordinates | 2988237..2989091 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3J51_RS30390 (J3J51_30390) | 2982730..2983818 | - | 1089 | WP_004184835.1 | porin | - |
| J3J51_RS30395 (J3J51_30395) | 2984253..2984570 | + | 318 | WP_004184916.1 | non-heme iron oxygenase ferredoxin subunit | - |
| J3J51_RS30400 (J3J51_30400) | 2984572..2984883 | + | 312 | WP_004184841.1 | hypothetical protein | - |
| J3J51_RS30405 (J3J51_30405) | 2984918..2985985 | + | 1068 | WP_004195457.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| J3J51_RS30410 (J3J51_30410) | 2985982..2986752 | + | 771 | WP_004524000.1 | SDR family oxidoreductase | - |
| J3J51_RS30415 (J3J51_30415) | 2986791..2987318 | + | 528 | WP_004524001.1 | cupin domain-containing protein | - |
| J3J51_RS30420 (J3J51_30420) | 2987335..2988240 | + | 906 | WP_004195452.1 | alpha/beta fold hydrolase | Toxin |
| J3J51_RS30425 (J3J51_30425) | 2988237..2989091 | + | 855 | WP_004195450.1 | IclR family transcriptional regulator | Antitoxin |
| J3J51_RS30430 (J3J51_30430) | 2989088..2989885 | + | 798 | WP_004540865.1 | SDR family oxidoreductase | - |
| J3J51_RS30435 (J3J51_30435) | 2989878..2991551 | + | 1674 | WP_004524004.1 | thiamine pyrophosphate-binding protein | - |
| J3J51_RS30440 (J3J51_30440) | 2991544..2992359 | + | 816 | WP_004195445.1 | aspartate dehydrogenase | - |
| J3J51_RS30445 (J3J51_30445) | 2992385..2993875 | + | 1491 | WP_004549581.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 302 a.a. Molecular weight: 30555.70 Da Isoelectric Point: 8.7357
>T196866 WP_004195452.1 NZ_CP071760:2987335-2988240 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIQRCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIQRCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
Download Length: 906 bp
>T196866 NZ_CP095497:2028041-2028337 [Burkholderia cepacia]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGACCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTACGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAGCTGGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGCGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGACCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTACGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAGCTGGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGCGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31152.56 Da Isoelectric Point: 6.8932
>AT196866 WP_004195450.1 NZ_CP071760:2988237-2989091 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
Download Length: 855 bp
>AT196866 NZ_CP095497:2028340-2028741 [Burkholderia cepacia]
ATGAAGTGTCCTGCATGCGGTGCTGCGAAGCTCGTCCGCGACACGCGAGACATCCCTTATACCTACAAGGGCCGGTCGAC
CGTCGTCCGCGCTGTCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAAGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTGCGCAAGAAG
CTGAAGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCACCCCGATCTGCTCGCCGAAGTCCGGGCCGCAT
AG
ATGAAGTGTCCTGCATGCGGTGCTGCGAAGCTCGTCCGCGACACGCGAGACATCCCTTATACCTACAAGGGCCGGTCGAC
CGTCGTCCGCGCTGTCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTACTGGATCTCGACGAAGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTGCGCAAGAAG
CTGAAGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCACCCCGATCTGCTCGCCGAAGTCCGGGCCGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3N4FRK3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3N4FRW8 |