Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 178921..180677 | Replicon | chromosome |
| Accession | NZ_CP071758 | ||
| Organism | Burkholderia pseudomallei strain VBP399 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | B1H5R2 |
| Locus tag | J3E55_RS18750 | Protein ID | WP_004524002.1 |
| Coordinates | 179772..180677 (-) | Length | 302 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q63LW2 |
| Locus tag | J3E55_RS18745 | Protein ID | WP_004195450.1 |
| Coordinates | 178921..179775 (-) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3E55_RS18725 (J3E55_18725) | 174137..175627 | - | 1491 | WP_004524006.1 | aldehyde dehydrogenase | - |
| J3E55_RS18730 (J3E55_18730) | 175653..176468 | - | 816 | WP_004528162.1 | aspartate dehydrogenase | - |
| J3E55_RS18735 (J3E55_18735) | 176461..178134 | - | 1674 | WP_004524004.1 | thiamine pyrophosphate-binding protein | - |
| J3E55_RS18740 (J3E55_18740) | 178127..178924 | - | 798 | WP_004540865.1 | SDR family oxidoreductase | - |
| J3E55_RS18745 (J3E55_18745) | 178921..179775 | - | 855 | WP_004195450.1 | IclR family transcriptional regulator | Antitoxin |
| J3E55_RS18750 (J3E55_18750) | 179772..180677 | - | 906 | WP_004524002.1 | alpha/beta fold hydrolase | Toxin |
| J3E55_RS18755 (J3E55_18755) | 180694..181221 | - | 528 | WP_004524001.1 | cupin domain-containing protein | - |
| J3E55_RS18760 (J3E55_18760) | 181260..182030 | - | 771 | WP_004524000.1 | SDR family oxidoreductase | - |
| J3E55_RS18765 (J3E55_18765) | 182027..183094 | - | 1068 | WP_004195457.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| J3E55_RS18770 (J3E55_18770) | 183129..183440 | - | 312 | WP_004184841.1 | hypothetical protein | - |
| J3E55_RS18775 (J3E55_18775) | 183442..183759 | - | 318 | WP_004184916.1 | non-heme iron oxygenase ferredoxin subunit | - |
| J3E55_RS18780 (J3E55_18780) | 184193..185281 | + | 1089 | WP_011853047.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 302 a.a. Molecular weight: 30556.69 Da Isoelectric Point: 8.4944
>T196858 WP_004524002.1 NZ_CP071758:c180677-179772 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
Download Length: 906 bp
>T196858 NZ_CP095475:c2523614-2523201 [Pseudoxanthomonas winnipegensis]
ATGAGCCGCGTGCTCTATCTGCTGGATACCAACATCTGCATCTACATCATCAATCGGCGTCCGCCTGGGGTGTTCGAGCA
TTTCGCTGGCCTGCAGATCGGGCAGATCGCGATTTCCAGCATCACCGGCGCCGAGTTGGACTATGGCGTGGCCAAGAGCG
GATCCCAGCGCAACCGTCAGGCGCTGGACAAGTTTCTGGCACCGCTGGATGTGCTTTCCTTCGATGAAGCCGCCATGCGT
CGTTATGGCGCGCTGCGCAGCGGATTGGAGCGTCAGGGCACACCGATCGGAGCAATGGATCAATTGATCGCGGCGCATGC
GCTGGCGCTGGATGCGGTGCTGGTCAGCAACAATCTGCGTGAGTTCGAACGTGTGCCTGGGCTGCGACTGGAGAACTGGG
TGTCCGCCGGATGA
ATGAGCCGCGTGCTCTATCTGCTGGATACCAACATCTGCATCTACATCATCAATCGGCGTCCGCCTGGGGTGTTCGAGCA
TTTCGCTGGCCTGCAGATCGGGCAGATCGCGATTTCCAGCATCACCGGCGCCGAGTTGGACTATGGCGTGGCCAAGAGCG
GATCCCAGCGCAACCGTCAGGCGCTGGACAAGTTTCTGGCACCGCTGGATGTGCTTTCCTTCGATGAAGCCGCCATGCGT
CGTTATGGCGCGCTGCGCAGCGGATTGGAGCGTCAGGGCACACCGATCGGAGCAATGGATCAATTGATCGCGGCGCATGC
GCTGGCGCTGGATGCGGTGCTGGTCAGCAACAATCTGCGTGAGTTCGAACGTGTGCCTGGGCTGCGACTGGAGAACTGGG
TGTCCGCCGGATGA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31152.56 Da Isoelectric Point: 6.8932
>AT196858 WP_004195450.1 NZ_CP071758:c179775-178921 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
Download Length: 855 bp
>AT196858 NZ_CP095475:c2523847-2523611 [Pseudoxanthomonas winnipegensis]
ATGACCACGACCGCAAAACTGTTCCAGTCCGGACGCAGTCAGGCCGTGCGCCTGCCCAAGGCCTTGCGCTTTGAAGGTGA
TCAAGTCATTGCCCGGCGCTTCGGCAACGGCGTGTTGTTGCTGCCGGTGGAGGCGCCCTGGCAGTTGATGCGTGAGGCAC
TCGAAGAGTTCGAGCCAGGCTTTGCCCTGCAACGCGACCAACCCGAACAGCAGGTGCGGGAGGACTGGTTGCGATGA
ATGACCACGACCGCAAAACTGTTCCAGTCCGGACGCAGTCAGGCCGTGCGCCTGCCCAAGGCCTTGCGCTTTGAAGGTGA
TCAAGTCATTGCCCGGCGCTTCGGCAACGGCGTGTTGTTGCTGCCGGTGGAGGCGCCCTGGCAGTTGATGCGTGAGGCAC
TCGAAGAGTTCGAGCCAGGCTTTGCCCTGCAACGCGACCAACCCGAACAGCAGGTGCGGGAGGACTGGTTGCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A095K1W1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3N4FRW8 |