Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 2395946..2397702 | Replicon | chromosome |
| Accession | NZ_CP071755 | ||
| Organism | Burkholderia pseudomallei strain VBP364 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | B1H5R2 |
| Locus tag | J3D99_RS27765 | Protein ID | WP_004524002.1 |
| Coordinates | 2396797..2397702 (-) | Length | 302 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q63LW2 |
| Locus tag | J3D99_RS27760 | Protein ID | WP_004195450.1 |
| Coordinates | 2395946..2396800 (-) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3D99_RS27740 (J3D99_016275) | 2391162..2392652 | - | 1491 | WP_004524006.1 | aldehyde dehydrogenase | - |
| J3D99_RS27745 (J3D99_016280) | 2392678..2393493 | - | 816 | WP_004195445.1 | aspartate dehydrogenase | - |
| J3D99_RS27750 (J3D99_016285) | 2393486..2395159 | - | 1674 | WP_004524004.1 | thiamine pyrophosphate-binding protein | - |
| J3D99_RS27755 (J3D99_016290) | 2395152..2395949 | - | 798 | WP_004195447.1 | SDR family oxidoreductase | - |
| J3D99_RS27760 (J3D99_016295) | 2395946..2396800 | - | 855 | WP_004195450.1 | IclR family transcriptional regulator | Antitoxin |
| J3D99_RS27765 (J3D99_016300) | 2396797..2397702 | - | 906 | WP_004524002.1 | alpha/beta fold hydrolase | Toxin |
| J3D99_RS27770 (J3D99_016305) | 2397719..2398246 | - | 528 | WP_004524001.1 | cupin domain-containing protein | - |
| J3D99_RS27775 (J3D99_016310) | 2398285..2399055 | - | 771 | WP_004524000.1 | SDR family oxidoreductase | - |
| J3D99_RS27780 (J3D99_016315) | 2399052..2400119 | - | 1068 | WP_004195457.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| J3D99_RS27785 (J3D99_016320) | 2400154..2400465 | - | 312 | WP_004184841.1 | hypothetical protein | - |
| J3D99_RS27790 (J3D99_016325) | 2400467..2400784 | - | 318 | WP_004184916.1 | non-heme iron oxygenase ferredoxin subunit | - |
| J3D99_RS27795 (J3D99_016330) | 2401219..2402307 | + | 1089 | WP_009939921.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 302 a.a. Molecular weight: 30556.69 Da Isoelectric Point: 8.4944
>T196856 WP_004524002.1 NZ_CP071755:c2397702-2396797 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
Download Length: 906 bp
>T196856 NZ_CP095463:c1459214-1458945 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31152.56 Da Isoelectric Point: 6.8932
>AT196856 WP_004195450.1 NZ_CP071755:c2396800-2395946 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
Download Length: 855 bp
>AT196856 NZ_CP095463:c1459431-1459204 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A095K1W1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3N4FRW8 |