Detailed information of TA system TA196855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1958291..1960044
• Replicon: chromosome
• Accession: NZ_CP071755
• Organism: Burkholderia pseudomallei strain VBP364

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q63JY0
• Locus tag: J3D99_RS26115
• Protein ID: WP_004188815.1
• Coordinates: 1958291..1959643 (-)
• Length: 451 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J3D99_RS26120
• Protein ID: WP_038792313.1
• Coordinates: 1959640..1960044 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3D99_RS26090 (J3D99_026040)	1954609..1954950	-	342	WP_207418509.1	hypothetical protein	-
J3D99_RS26095 (J3D99_026045)	1955227..1956180	-	954	WP_004539421.1	agmatinase	-
J3D99_RS26100 (J3D99_026050)	1956347..1957261	+	915	WP_004545706.1	LysR family transcriptional regulator	-
J3D99_RS26105 (J3D99_026055)	1957424..1957570	+	147	WP_004199790.1	hypothetical protein	-
J3D99_RS26110 (J3D99_026060)	1957671..1958123	+	453	WP_004198842.1	hypothetical protein	-
J3D99_RS26115 (J3D99_026065)	1958291..1959643	-	1353	WP_004188815.1	type II toxin-antitoxin system HipA family toxin	Toxin
J3D99_RS26120 (J3D99_026070)	1959640..1960044	-	405	WP_038792313.1	helix-turn-helix transcriptional regulator	Antitoxin
J3D99_RS26125 (J3D99_026075)	1960382..1960645	-	264	WP_004199789.1	hypothetical protein	-
J3D99_RS26130 (J3D99_026080)	1961110..1963506	+	2397	WP_045588572.1	cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (158-408)

Antitoxin

• Cro/C1-type helix-turn-helix domain (22-71)

Sequences

Toxin

Protein

• Length: 451 a.a.
• Molecular weight: 49848.83 Da
• Isoelectric Point: 9.6807

>T196855 WP_004188815.1 NZ_CP071755:c1959643-1958291 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Nucleotide

• Length: 1353 bp

>T196855 NZ_CP095463:1200330-1200587 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14307.64 Da
• Isoelectric Point: 11.7233

>AT196855 WP_038792313.1 NZ_CP071755:c1960044-1959640 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARAGARRAVPPASAPAPSAAGRPPRPARKRAAPKKREDW

Nucleotide

• Length: 405 bp

>AT196855 NZ_CP095463:1200095-1200346 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Structures

Toxin

• AlphaFold DB: A0A3N4FSX2