Detailed information of TA system TA196854

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1831514..1832070
• Replicon: chromosome
• Accession: NZ_CP071754
• Organism: Burkholderia pseudomallei strain VBP364

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J3D99_RS08190
• Protein ID: WP_229655145.1
• Coordinates: 1831514..1831765 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J3D99_RS08195
• Protein ID: WP_038780841.1
• Coordinates: 1831792..1832070 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3D99_RS08170 (J3D99_00140)	1826779..1827300	+	522	WP_038780832.1	hypothetical protein	-
J3D99_RS08175 (J3D99_00145)	1827334..1830615	-	3282	WP_198046341.1	VPA1262 family protein	-
J3D99_RS08180 (J3D99_00150)	1830757..1831008	-	252	WP_198046342.1	hypothetical protein	-
J3D99_RS30820	1831088..1831216	-	129	WP_256704163.1	hypothetical protein	-
J3D99_RS08185 (J3D99_00155)	1831209..1831511	-	303	WP_038780836.1	hypothetical protein	-
J3D99_RS08190 (J3D99_00160)	1831514..1831765	-	252	WP_229655145.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J3D99_RS08195 (J3D99_00165)	1831792..1832070	-	279	WP_038780841.1	CopG family ribbon-helix-helix protein	Antitoxin
J3D99_RS08200 (J3D99_00170)	1832173..1834182	-	2010	WP_223872105.1	relaxase/mobilization nuclease domain-containing protein	-
J3D99_RS08205 (J3D99_00175)	1834185..1834385	-	201	WP_223872106.1	plasmid mobilization protein MobA	-
J3D99_RS08210 (J3D99_00180)	1834943..1835200	+	258	WP_076927500.1	hypothetical protein	-
J3D99_RS08215 (J3D99_00185)	1835281..1835799	+	519	WP_207418111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1825208..1845373	20165

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9556.78 Da
• Isoelectric Point: 9.5559

>T196854 WP_229655145.1 NZ_CP071754:c1831765-1831514 [Burkholderia pseudomallei]
MQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEQYREWPIDFGDSGYVARYRFDGDAVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T196854 NZ_CP095463:713264-713524 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10853.13 Da
• Isoelectric Point: 4.8052

>AT196854 WP_038780841.1 NZ_CP071754:c1832070-1831792 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREVLNQDTLKAWDEFQETGLHATAEEVDKWLASWG
TENELPPPECHK

Nucleotide

• Length: 279 bp

>AT196854 NZ_CP095463:713041-713262 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG