Detailed information of TA system TA196848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2701357..2701913
• Replicon: chromosome
• Accession: NZ_CP071751
• Organism: Burkholderia pseudomallei strain VBM23831

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J3C54_RS12275
• Protein ID: WP_229655145.1
• Coordinates: 2701662..2701913 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J3C54_RS12270
• Protein ID: WP_038780841.1
• Coordinates: 2701357..2701635 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3C54_RS12250 (J3C54_12250)	2697250..2698146	-	897	WP_122781805.1	hypothetical protein	-
J3C54_RS12255 (J3C54_12255)	2698227..2698484	-	258	WP_076927500.1	hypothetical protein	-
J3C54_RS12260 (J3C54_12260)	2698973..2699242	+	270	WP_183159590.1	plasmid mobilization protein MobA	-
J3C54_RS12265 (J3C54_12265)	2699245..2701254	+	2010	WP_223872105.1	relaxase/mobilization nuclease domain-containing protein	-
J3C54_RS12270 (J3C54_12270)	2701357..2701635	+	279	WP_038780841.1	CopG family ribbon-helix-helix protein	Antitoxin
J3C54_RS12275 (J3C54_12275)	2701662..2701913	+	252	WP_229655145.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J3C54_RS12280 (J3C54_12280)	2701916..2702218	+	303	WP_038780836.1	hypothetical protein	-
J3C54_RS32430	2702211..2702339	+	129	WP_256704163.1	hypothetical protein	-
J3C54_RS12285 (J3C54_12285)	2702419..2702670	+	252	WP_198046342.1	hypothetical protein	-
J3C54_RS12290 (J3C54_12290)	2702812..2706093	+	3282	WP_198046341.1	VPA1262 family protein	-
J3C54_RS12295 (J3C54_12295)	2706127..2706648	-	522	WP_038780832.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2689928..2708219	18291

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9556.78 Da
• Isoelectric Point: 9.5559

>T196848 WP_229655145.1 NZ_CP071751:2701662-2701913 [Burkholderia pseudomallei]
MQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEQYREWPIDFGDSGYVARYRFDGDAVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T196848 NZ_CP095451:c54183-53767 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10853.13 Da
• Isoelectric Point: 4.8052

>AT196848 WP_038780841.1 NZ_CP071751:2701357-2701635 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREVLNQDTLKAWDEFQETGLHATAEEVDKWLASWG
TENELPPPECHK

Nucleotide

• Length: 279 bp

>AT196848 NZ_CP095451:c54410-54180 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA