Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 3056864..3058620 | Replicon | chromosome |
| Accession | NZ_CP071747 | ||
| Organism | Burkholderia pseudomallei strain VBM21822 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | J3B45_RS30695 | Protein ID | WP_207864883.1 |
| Coordinates | 3056864..3057769 (+) | Length | 302 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q63LW2 |
| Locus tag | J3B45_RS30700 | Protein ID | WP_004195450.1 |
| Coordinates | 3057766..3058620 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3B45_RS30665 (J3B45_30665) | 3052259..3053347 | - | 1089 | WP_004184835.1 | porin | - |
| J3B45_RS30670 (J3B45_30670) | 3053782..3054099 | + | 318 | WP_004184916.1 | non-heme iron oxygenase ferredoxin subunit | - |
| J3B45_RS30675 (J3B45_30675) | 3054101..3054412 | + | 312 | WP_004184841.1 | hypothetical protein | - |
| J3B45_RS30680 (J3B45_30680) | 3054447..3055514 | + | 1068 | WP_004195457.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| J3B45_RS30685 (J3B45_30685) | 3055511..3056281 | + | 771 | WP_004524000.1 | SDR family oxidoreductase | - |
| J3B45_RS30690 (J3B45_30690) | 3056320..3056847 | + | 528 | WP_004524001.1 | cupin domain-containing protein | - |
| J3B45_RS30695 (J3B45_30695) | 3056864..3057769 | + | 906 | WP_207864883.1 | alpha/beta fold hydrolase | Toxin |
| J3B45_RS30700 (J3B45_30700) | 3057766..3058620 | + | 855 | WP_004195450.1 | IclR family transcriptional regulator | Antitoxin |
| J3B45_RS30705 (J3B45_30705) | 3058617..3059414 | + | 798 | WP_004524003.1 | SDR family oxidoreductase | - |
| J3B45_RS30710 (J3B45_30710) | 3059407..3061080 | + | 1674 | WP_004524004.1 | thiamine pyrophosphate-binding protein | - |
| J3B45_RS30715 (J3B45_30715) | 3061073..3061888 | + | 816 | WP_004195445.1 | aspartate dehydrogenase | - |
| J3B45_RS30720 (J3B45_30720) | 3061914..3063404 | + | 1491 | WP_004524006.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 302 a.a. Molecular weight: 30528.63 Da Isoelectric Point: 8.4944
>T196840 WP_207864883.1 NZ_CP071747:3056864-3057769 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVALLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVALLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP
Download Length: 906 bp
>T196840 NZ_CP095448:3652613-3652831 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31152.56 Da Isoelectric Point: 6.8932
>AT196840 WP_004195450.1 NZ_CP071747:3057766-3058620 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR
Download Length: 855 bp
>AT196840 NZ_CP095448:3652213-3652587 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACTTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTCCAAAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACTTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTCCAAAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|