Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT_toxin-BrnA |
| Location | 2332215..2332704 | Replicon | chromosome |
| Accession | NZ_CP071747 | ||
| Organism | Burkholderia pseudomallei strain VBM21822 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | - |
| Locus tag | J3B45_RS27715 | Protein ID | WP_038734759.1 |
| Coordinates | 2332215..2332436 (+) | Length | 74 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | Q63NA3 |
| Locus tag | J3B45_RS27720 | Protein ID | WP_004525420.1 |
| Coordinates | 2332420..2332704 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3B45_RS27675 (J3B45_27675) | 2328745..2329164 | - | 420 | WP_243435357.1 | SPFH domain-containing protein | - |
| J3B45_RS27680 (J3B45_27680) | 2329161..2329310 | - | 150 | WP_004542626.1 | bacteriophage protein Gp44 | - |
| J3B45_RS27685 (J3B45_27685) | 2329566..2330147 | + | 582 | WP_004542548.1 | hypothetical protein | - |
| J3B45_RS27690 (J3B45_27690) | 2330378..2330596 | - | 219 | WP_004552392.1 | hypothetical protein | - |
| J3B45_RS27695 (J3B45_27695) | 2330644..2330802 | - | 159 | WP_004549802.1 | hypothetical protein | - |
| J3B45_RS27700 (J3B45_27700) | 2330799..2331041 | - | 243 | WP_004545584.1 | hypothetical protein | - |
| J3B45_RS27705 (J3B45_27705) | 2331179..2331310 | - | 132 | WP_009923452.1 | bacteriophage protein Gp48 | - |
| J3B45_RS27710 (J3B45_27710) | 2331320..2331595 | - | 276 | WP_038716556.1 | hypothetical protein | - |
| J3B45_RS27715 (J3B45_27715) | 2332215..2332436 | + | 222 | WP_038734759.1 | BrnT family toxin | Toxin |
| J3B45_RS27720 (J3B45_27720) | 2332420..2332704 | + | 285 | WP_004525420.1 | BrnA antitoxin family protein | Antitoxin |
| J3B45_RS27725 (J3B45_27725) | 2333351..2333734 | + | 384 | Protein_1940 | integrase core domain-containing protein | - |
| J3B45_RS27730 (J3B45_27730) | 2333733..2334125 | + | 393 | Protein_1941 | IS110 family transposase | - |
| J3B45_RS27735 (J3B45_27735) | 2334352..2334468 | - | 117 | Protein_1942 | IS3 family transposase | - |
| J3B45_RS27740 (J3B45_27740) | 2334734..2336194 | + | 1461 | WP_207864755.1 | metallophosphoesterase | - |
| J3B45_RS27745 (J3B45_27745) | 2336353..2337615 | + | 1263 | WP_004551329.1 | cytochrome c peroxidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2316899..2336194 | 19295 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 74 a.a. Molecular weight: 8606.71 Da Isoelectric Point: 8.4920
>T196839 WP_038734759.1 NZ_CP071747:2332215-2332436 [Burkholderia pseudomallei]
MECRWRLQRNSTGQDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKREAKSYVEQA
MECRWRLQRNSTGQDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKREAKSYVEQA
Download Length: 222 bp
>T196839 NZ_CP095448:3293332-3293718 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10697.10 Da Isoelectric Point: 5.8930
>AT196839 WP_004525420.1 NZ_CP071747:2332420-2332704 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA
Download Length: 285 bp
>AT196839 NZ_CP095448:3293708-3294037 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|