Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT_toxin-BrnA |
| Location | 427503..428040 | Replicon | chromosome |
| Accession | NZ_CP071747 | ||
| Organism | Burkholderia pseudomallei strain VBM21822 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | Q2T6G2 |
| Locus tag | J3B45_RS19780 | Protein ID | WP_004549731.1 |
| Coordinates | 427771..428040 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | Q2T6G1 |
| Locus tag | J3B45_RS19775 | Protein ID | WP_011401115.1 |
| Coordinates | 427503..427787 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3B45_RS19740 (J3B45_19740) | 423358..423543 | - | 186 | WP_015967349.1 | hypothetical protein | - |
| J3B45_RS19745 (J3B45_19745) | 423540..425252 | - | 1713 | WP_207865006.1 | terminase large subunit | - |
| J3B45_RS19750 (J3B45_19750) | 425262..425747 | - | 486 | WP_207865008.1 | phage terminase small subunit P27 family | - |
| J3B45_RS19755 (J3B45_19755) | 425895..426251 | - | 357 | WP_004548856.1 | HNH endonuclease | - |
| J3B45_RS19760 (J3B45_19760) | 426310..426567 | + | 258 | WP_004549735.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J3B45_RS19765 (J3B45_19765) | 426564..426950 | + | 387 | WP_004526660.1 | helix-turn-helix transcriptional regulator | - |
| J3B45_RS19770 (J3B45_19770) | 427131..427325 | - | 195 | WP_207865010.1 | DUF2158 domain-containing protein | - |
| J3B45_RS19775 (J3B45_19775) | 427503..427787 | - | 285 | WP_011401115.1 | BrnA antitoxin family protein | Antitoxin |
| J3B45_RS19780 (J3B45_19780) | 427771..428040 | - | 270 | WP_004549731.1 | BrnT family toxin | Toxin |
| J3B45_RS19785 (J3B45_19785) | 428090..428533 | - | 444 | WP_076888524.1 | hypothetical protein | - |
| J3B45_RS19790 (J3B45_19790) | 428530..428769 | - | 240 | WP_243435371.1 | hypothetical protein | - |
| J3B45_RS19795 (J3B45_19795) | 429101..429526 | - | 426 | WP_207865012.1 | DUF1364 family protein | - |
| J3B45_RS19800 (J3B45_19800) | 429523..429897 | - | 375 | WP_038731729.1 | hypothetical protein | - |
| J3B45_RS19805 (J3B45_19805) | 429894..430445 | - | 552 | WP_122884277.1 | DUF1064 domain-containing protein | - |
| J3B45_RS19810 (J3B45_19810) | 430442..431434 | - | 993 | WP_076809500.1 | helix-turn-helix domain-containing protein | - |
| J3B45_RS19815 (J3B45_19815) | 431588..431848 | - | 261 | WP_004526650.1 | helix-turn-helix domain-containing protein | - |
| J3B45_RS19820 (J3B45_19820) | 431845..432666 | - | 822 | WP_004526649.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 394700..450418 | 55718 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10157.46 Da Isoelectric Point: 5.6831
>T196837 WP_004549731.1 NZ_CP071747:c428040-427771 [Burkholderia pseudomallei]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA
Download Length: 270 bp
>T196837 NZ_CP095448:2426531-2426707 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10669.09 Da Isoelectric Point: 5.8930
>AT196837 WP_011401115.1 NZ_CP071747:c427787-427503 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLKEHQPA
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLKEHQPA
Download Length: 285 bp
>AT196837 NZ_CP095448:2426753-2427169 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|