Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1398240..1398796 Replicon chromosome
Accession NZ_CP071746
Organism Burkholderia pseudomallei strain VBM21822

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag J3B45_RS06615 Protein ID WP_229655145.1
Coordinates 1398545..1398796 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J3B45_RS06610 Protein ID WP_038780841.1
Coordinates 1398240..1398518 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3B45_RS06585 (J3B45_06585) 1393346..1394466 + 1121 WP_207864366.1 IS3 family transposase -
J3B45_RS06590 (J3B45_06590) 1394511..1395029 - 519 WP_207418111.1 hypothetical protein -
J3B45_RS06595 (J3B45_06595) 1395110..1395367 - 258 WP_076927500.1 hypothetical protein -
J3B45_RS06600 (J3B45_06600) 1395856..1396125 + 270 WP_183159590.1 plasmid mobilization protein MobA -
J3B45_RS06605 (J3B45_06605) 1396128..1398137 + 2010 WP_223872105.1 relaxase/mobilization nuclease domain-containing protein -
J3B45_RS06610 (J3B45_06610) 1398240..1398518 + 279 WP_038780841.1 CopG family ribbon-helix-helix protein Antitoxin
J3B45_RS06615 (J3B45_06615) 1398545..1398796 + 252 WP_229655145.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J3B45_RS06620 (J3B45_06620) 1398799..1399101 + 303 WP_038780836.1 hypothetical protein -
J3B45_RS32740 1399094..1399222 + 129 WP_256704163.1 hypothetical protein -
J3B45_RS06625 (J3B45_06625) 1399302..1399553 + 252 WP_198046342.1 hypothetical protein -
J3B45_RS06630 (J3B45_06630) 1399695..1402976 + 3282 WP_198046341.1 VPA1262 family protein -
J3B45_RS06635 (J3B45_06635) 1403010..1403531 - 522 WP_038780832.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1384709..1405102 20393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-81)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9556.78 Da        Isoelectric Point: 9.5559

>T196836 WP_229655145.1 NZ_CP071746:1398545-1398796 [Burkholderia pseudomallei]
MQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEQYREWPIDFGDSGYVARYRFDGDAVTILAVRHQKE
AGY

Download         Length: 252 bp

>T196836 NZ_CP095448:c2222515-2222408 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10853.13 Da        Isoelectric Point: 4.8052

>AT196836 WP_038780841.1 NZ_CP071746:1398240-1398518 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREVLNQDTLKAWDEFQETGLHATAEEVDKWLASWG
TENELPPPECHK

Download         Length: 279 bp

>AT196836 NZ_CP095448:2222568-2222629 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References