Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1614601..1615598 Replicon chromosome
Accession NZ_CP071734
Organism Klebsiella variicola strain KGB_1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KGB1_RS07890 Protein ID WP_232690963.1
Coordinates 1615044..1615598 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KGB1_RS07885 Protein ID WP_042947869.1
Coordinates 1614601..1615047 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGB1_RS07870 (KGB1_07880) 1610896..1611894 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
KGB1_RS07875 (KGB1_07885) 1612013..1613533 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
KGB1_RS07880 (KGB1_07890) 1613549..1614559 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
KGB1_RS07885 (KGB1_07895) 1614601..1615047 - 447 WP_042947869.1 helix-turn-helix transcriptional regulator Antitoxin
KGB1_RS07890 1615044..1615598 - 555 WP_232690963.1 HipA domain-containing protein Toxin
KGB1_RS07895 1615627..1616148 - 522 WP_023340544.1 hypothetical protein -
KGB1_RS07900 (KGB1_07905) 1616263..1616994 - 732 WP_008804033.1 outer membrane permeability protein SanA -
KGB1_RS07905 (KGB1_07910) 1617271..1618155 - 885 WP_012967554.1 cytidine deaminase -
KGB1_RS07910 (KGB1_07915) 1618284..1618979 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
KGB1_RS07915 (KGB1_07920) 1618969..1619373 - 405 WP_023340543.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20724.01 Da        Isoelectric Point: 5.2868

>T196820 WP_232690963.1 NZ_CP071734:c1615598-1615044 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDYETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

>T196820 NZ_CP095429:193292-193735 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16410.08 Da        Isoelectric Point: 10.5417

>AT196820 WP_042947869.1 NZ_CP071734:c1615047-1614601 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRLEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp

>AT196820 NZ_CP095429:193065-193295 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References