Detailed information of TA system TA196817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 2547866..2548389
• Replicon: chromosome
• Accession: NZ_CP071733
• Organism: Bifidobacterium longum subsp. infantis strain JCM 7010

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: BLI010_RS11300
• Protein ID: WP_206649247.1
• Coordinates: 2547866..2548120 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: -
• Locus tag: BLI010_RS11305
• Protein ID: WP_229040743.1
• Coordinates: 2548120..2548389 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLI010_RS11275 (BLI010_11275)	2543537..2545213	-	1677	WP_207851095.1	ATP-binding protein	-
BLI010_RS11280 (BLI010_11280)	2545302..2545562	-	261	WP_226746504.1	hypothetical protein	-
BLI010_RS11285 (BLI010_11285)	2545816..2546334	+	519	WP_234923883.1	hypothetical protein	-
BLI010_RS11290 (BLI010_11290)	2546345..2546725	+	381	WP_206648560.1	hypothetical protein	-
BLI010_RS11295 (BLI010_11295)	2546808..2547872	+	1065	WP_206648559.1	hypothetical protein	-
BLI010_RS11300 (BLI010_11300)	2547866..2548120	-	255	WP_206649247.1	Txe/YoeB family addiction module toxin	Toxin
BLI010_RS11305 (BLI010_11305)	2548120..2548389	-	270	WP_229040743.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BLI010_RS11310 (BLI010_11310)	2548568..2548948	+	381	WP_206648558.1	hypothetical protein	-
BLI010_RS11315 (BLI010_11315)	2548971..2549393	+	423	WP_206648557.1	hypothetical protein	-
BLI010_RS11320 (BLI010_11320)	2549478..2549819	+	342	WP_227484959.1	hypothetical protein	-
BLI010_RS11325 (BLI010_11325)	2549970..2550347	-	378	WP_065436686.1	hypothetical protein	-
BLI010_RS11330 (BLI010_11330)	2550452..2551903	-	1452	WP_131212375.1	hypothetical protein	-
BLI010_RS11335 (BLI010_11335)	2552073..2552510	-	438	WP_165506826.1	hypothetical protein	-
BLI010_RS11340 (BLI010_11340)	2552778..2553095	-	318	WP_065436683.1	HigA family addiction module antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2483691..2588311	104620

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-77)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9936.34 Da
• Isoelectric Point: 8.4862

>T196817 WP_206649247.1 NZ_CP071733:c2548120-2547866 [Bifidobacterium longum subsp. infantis]
MLLCWTEDAWADYLYWQSQDRKTLKRVNTLIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCTLSA
KDHY

Nucleotide

• Length: 255 bp

>T196817 NZ_CP095428:4813631-4814038 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10053.32 Da
• Isoelectric Point: 4.3407

>AT196817 WP_229040743.1 NZ_CP071733:c2548389-2548120 [Bifidobacterium longum subsp. infantis]
MMTQAVAYSNFRANLKTYMRRVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQTM
AHDLVEAGA

Nucleotide

• Length: 270 bp

>AT196817 NZ_CP095428:4813384-4813650 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA