Detailed information of TA system TA196815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1552180..1552745
• Replicon: chromosome
• Accession: NZ_CP071733
• Organism: Bifidobacterium longum subsp. infantis strain JCM 7010

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BLI010_RS07065
• Protein ID: WP_206648901.1
• Coordinates: 1552455..1552745 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B7GSH1
• Locus tag: BLI010_RS07060
• Protein ID: WP_012576473.1
• Coordinates: 1552180..1552458 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BLI010_RS07040 (BLI010_07040)	1549186..1549740	+	555	WP_206649259.1	hypothetical protein	-
BLI010_RS07045 (BLI010_07045)	1550162..1550806	-	645	WP_206648904.1	hypothetical protein	-
BLI010_RS11975	1551074..1551295	+	222	Protein_1377	transposase	-
BLI010_RS07055 (BLI010_07055)	1551416..1551877	-	462	WP_207851083.1	hypothetical protein	-
BLI010_RS07060 (BLI010_07060)	1552180..1552458	+	279	WP_012576473.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BLI010_RS07065 (BLI010_07065)	1552455..1552745	+	291	WP_206648901.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BLI010_RS07070 (BLI010_07070)	1553154..1554035	+	882	WP_082247995.1	MurR/RpiR family transcriptional regulator	-
BLI010_RS07075 (BLI010_07075)	1554192..1555232	+	1041	WP_206648900.1	ABC transporter substrate-binding protein	-
BLI010_RS07080 (BLI010_07080)	1555327..1556886	+	1560	WP_159426788.1	iron ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1541702..1563159	21457

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10897.62 Da
• Isoelectric Point: 10.2245

>T196815 WP_206648901.1 NZ_CP071733:1552455-1552745 [Bifidobacterium longum subsp. infantis]
MSSIRYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Nucleotide

• Length: 291 bp

>T196815 NZ_CP095428:4198490-4198837 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10202.63 Da
• Isoelectric Point: 6.3216

>AT196815 WP_012576473.1 NZ_CP071733:1552180-1552458 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Nucleotide

• Length: 279 bp

>AT196815 NZ_CP095428:4198837-4199136 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0A8MHE5