Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 209122..209688 Replicon chromosome
Accession NZ_CP071733
Organism Bifidobacterium longum subsp. infantis strain JCM 7010

Toxin (Protein)


Gene name relE Uniprot ID A0A0L7BQL3
Locus tag BLI010_RS01010 Protein ID WP_029680114.1
Coordinates 209122..209415 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1S2VZL2
Locus tag BLI010_RS01015 Protein ID WP_071477905.1
Coordinates 209419..209688 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLI010_RS00975 (BLI010_00975) 205035..205901 - 867 WP_234923863.1 MFS transporter -
BLI010_RS00980 (BLI010_00980) 206070..206477 - 408 WP_207851104.1 hypothetical protein -
BLI010_RS00985 (BLI010_00985) 206554..206847 - 294 WP_206648447.1 hypothetical protein -
BLI010_RS00990 (BLI010_00990) 206940..207581 - 642 WP_206648446.1 moaA protein -
BLI010_RS00995 (BLI010_00995) 207795..207959 + 165 WP_227484938.1 antitoxin VbhA family protein -
BLI010_RS01000 (BLI010_01000) 208015..208578 + 564 WP_227484937.1 Fic family protein -
BLI010_RS01005 (BLI010_01005) 208645..209064 - 420 WP_227484936.1 hypothetical protein -
BLI010_RS01010 (BLI010_01010) 209122..209415 - 294 WP_029680114.1 type II toxin-antitoxin system YafQ family toxin Toxin
BLI010_RS01015 (BLI010_01015) 209419..209688 - 270 WP_071477905.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BLI010_RS11795 209856..210044 - 189 WP_227484935.1 hypothetical protein -
BLI010_RS01025 (BLI010_01025) 210313..210525 - 213 Protein_202 hypothetical protein -
BLI010_RS01030 (BLI010_01030) 210510..210992 + 483 WP_227484934.1 hypothetical protein -
BLI010_RS01035 (BLI010_01035) 211394..211534 - 141 WP_007056287.1 hypothetical protein -
BLI010_RS01040 (BLI010_01040) 211874..213151 - 1278 WP_193642223.1 IS256-like element ISBlo8 family transposase -
BLI010_RS01045 (BLI010_01045) 213444..214577 + 1134 WP_206648445.1 IS1249 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 196151..215589 19438
- flank IS/Tn - - 211874..213175 1301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-88)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11160.90 Da        Isoelectric Point: 9.7881

>T196812 WP_029680114.1 NZ_CP071733:c209415-209122 [Bifidobacterium longum subsp. infantis]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T196812 NZ_CP095428:c3442286-3441369 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9888.18 Da        Isoelectric Point: 4.7872

>AT196812 WP_071477905.1 NZ_CP071733:c209688-209419 [Bifidobacterium longum subsp. infantis]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGRPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT196812 NZ_CP095428:c3443050-3442292 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7BQL3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2VZL2

References