Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1297850..1298436 Replicon chromosome
Accession NZ_CP071731
Organism Pseudomonas aeruginosa strain LYSZa2

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag LYSZa2_RS06140 Protein ID WP_003120987.1
Coordinates 1298137..1298436 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LYSZa2_RS06135 Protein ID WP_003448662.1
Coordinates 1297850..1298140 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYSZa2_RS06115 (LYSZa2_06115) 1293001..1293210 + 210 WP_003105733.1 cold-shock protein -
LYSZa2_RS06120 (LYSZa2_06120) 1293432..1295321 + 1890 WP_016851610.1 hypothetical protein -
LYSZa2_RS06125 (LYSZa2_06125) 1295318..1297294 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
LYSZa2_RS06130 (LYSZa2_06130) 1297435..1297779 + 345 WP_016851612.1 hypothetical protein -
LYSZa2_RS06135 (LYSZa2_06135) 1297850..1298140 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
LYSZa2_RS06140 (LYSZa2_06140) 1298137..1298436 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LYSZa2_RS06145 (LYSZa2_06145) 1298638..1299759 + 1122 WP_021263359.1 TcpQ domain-containing protein -
LYSZa2_RS06150 (LYSZa2_06150) 1299759..1301468 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
LYSZa2_RS06155 (LYSZa2_06155) 1301472..1302797 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
LYSZa2_RS06160 (LYSZa2_06160) 1302787..1303320 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1270871..1413033 142162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T196805 WP_003120987.1 NZ_CP071731:c1298436-1298137 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

>T196805 NZ_CP095427:c35397-35248 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT196805 WP_003448662.1 NZ_CP071731:c1298140-1297850 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp

>AT196805 NZ_CP095427:35442-35501 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References