196800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2764254..2764759 Replicon chromosome
Accession NZ_CP071730
Organism Pseudomonas aeruginosa strain LYSZa5

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag LYSZa5_RS12930 Protein ID WP_003083773.1
Coordinates 2764254..2764535 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag LYSZa5_RS12935 Protein ID WP_003112628.1
Coordinates 2764532..2764759 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYSZa5_RS12905 (LYSZa5_12905) 2759505..2760854 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
LYSZa5_RS12910 (LYSZa5_12910) 2760903..2761589 + 687 WP_004351997.1 FadR/GntR family transcriptional regulator -
LYSZa5_RS12915 (LYSZa5_12915) 2761690..2762424 + 735 WP_003117208.1 GntR family transcriptional regulator -
LYSZa5_RS12920 (LYSZa5_12920) 2762604..2763014 + 411 WP_003101225.1 aegerolysin family protein -
LYSZa5_RS12925 (LYSZa5_12925) 2763046..2763954 - 909 WP_077144633.1 LysR family transcriptional regulator -
LYSZa5_RS12930 (LYSZa5_12930) 2764254..2764535 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
LYSZa5_RS12935 (LYSZa5_12935) 2764532..2764759 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
LYSZa5_RS12940 (LYSZa5_12940) 2764934..2765554 - 621 WP_009314940.1 hypothetical protein -
LYSZa5_RS12945 (LYSZa5_12945) 2765662..2766162 + 501 WP_003112629.1 LEA type 2 family protein -
LYSZa5_RS12950 (LYSZa5_12950) 2766235..2766576 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
LYSZa5_RS12955 (LYSZa5_12955) 2766658..2768085 - 1428 WP_003083784.1 GABA permease -
LYSZa5_RS12960 (LYSZa5_12960) 2768254..2769747 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T196800 WP_003083773.1 NZ_CP071730:c2764535-2764254 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T196800 NZ_CP095426:c4875661-4875377 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT196800 WP_003112628.1 NZ_CP071730:c2764759-2764532 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT196800 NZ_CP095426:c4875893-4875651 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References