Detailed information of TA system TA196796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 595026..596284
• Replicon: chromosome
• Accession: NZ_CP071730
• Organism: Pseudomonas aeruginosa strain LYSZa5

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LYSZa5_RS02790
• Protein ID: WP_023084953.1
• Coordinates: 595026..595781 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: LYSZa5_RS02795
• Protein ID: WP_003086329.1
• Coordinates: 595916..596284 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LYSZa5_RS02780 (LYSZa5_02780)	590199..592742	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
LYSZa5_RS02785 (LYSZa5_02785)	592897..594258	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
LYSZa5_RS02790 (LYSZa5_02790)	595026..595781	-	756	WP_023084953.1	RES family NAD+ phosphorylase	Toxin
LYSZa5_RS02795 (LYSZa5_02795)	595916..596284	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
LYSZa5_RS02800 (LYSZa5_02800)	596357..597643	-	1287	WP_077144871.1	FAD-binding oxidoreductase	-
LYSZa5_RS02805 (LYSZa5_02805)	597699..599192	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
LYSZa5_RS02810 (LYSZa5_02810)	599367..599843	+	477	WP_003140638.1	hypothetical protein	-
LYSZa5_RS02815 (LYSZa5_02815)	599846..600121	-	276	WP_169057979.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28310.49 Da
• Isoelectric Point: 7.7294

>T196796 WP_023084953.1 NZ_CP071730:c595781-595026 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T196796 NZ_CP095426:2071349-2071451 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT196796 WP_003086329.1 NZ_CP071730:c596284-595916 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT196796 NZ_CP095426:c2071458-2071313 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Antitoxin

• AlphaFold DB: V6AJU7