Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 176062..176654 Replicon plasmid pMB04
Accession NZ_CP071721
Organism Acaryochloris sp. 'Moss Beach'

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HRE53_RS31510 Protein ID WP_235112341.1
Coordinates 176400..176654 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HRE53_RS31505 Protein ID WP_235112338.1
Coordinates 176062..176403 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRE53_RS31500 (HRE53_30665) 172005..175808 - 3804 WP_235112337.1 hypothetical protein -
HRE53_RS31505 (HRE53_30670) 176062..176403 - 342 WP_235112338.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HRE53_RS31510 (HRE53_30675) 176400..176654 - 255 WP_235112341.1 type II toxin-antitoxin system HicA family toxin Toxin
HRE53_RS31515 (HRE53_30680) 176884..177210 + 327 WP_235112342.1 carbon dioxide-concentrating mechanism protein CcmK -
HRE53_RS31520 (HRE53_30685) 177259..177543 - 285 WP_235112343.1 hypothetical protein -
HRE53_RS31525 (HRE53_30690) 177562..177897 + 336 WP_235112344.1 hypothetical protein -
HRE53_RS31530 (HRE53_30695) 177993..178598 + 606 WP_235112347.1 ParA family protein -
HRE53_RS31535 (HRE53_30700) 178591..179319 + 729 WP_235112349.1 ParB N-terminal domain-containing protein -
HRE53_RS31540 (HRE53_30705) 179332..180072 - 741 WP_235112351.1 intradiol ring-cleavage dioxygenase -
HRE53_RS31545 (HRE53_30710) 180111..180473 - 363 WP_235112353.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..180652 180652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9949.71 Da        Isoelectric Point: 10.5399

>T196795 WP_235112341.1 NZ_CP071721:c176654-176400 [Acaryochloris sp. 'Moss Beach']
MTRKEKLVKRFLSRPKDFTWDELVVLLAFFQFSEVSTGKTGGSRRRFINEEGLVISLHKPHPRKILKKYQMEQVMDILEQ
EGLL

Download         Length: 255 bp

>T196795 NZ_CP095426:876749-877156 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12911.47 Da        Isoelectric Point: 4.9152

>AT196795 WP_235112338.1 NZ_CP071721:c176403-176062 [Acaryochloris sp. 'Moss Beach']
MKNMMEYQGYFGSVNFSDEDEVFFGKVEFIRSLISYEGTDVQSLKSAFHEAVEEYLADCADHEIKPERPFKGSFNIRPGT
QLHRRAAIAAQQRGINLNTLVTEALENYLQPSK

Download         Length: 342 bp

>AT196795 NZ_CP095426:876502-876768 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References