Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4393205..4393830 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JQM62_RS21770 Protein ID WP_000911330.1
Coordinates 4393432..4393830 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JQM62_RS21765 Protein ID WP_000450524.1
Coordinates 4393205..4393432 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS21740 (4389007) 4389007..4389477 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JQM62_RS21745 (4389477) 4389477..4390049 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JQM62_RS21750 (4390195) 4390195..4391073 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JQM62_RS21755 (4391090) 4391090..4392124 + 1035 WP_001368798.1 outer membrane protein assembly factor BamC -
JQM62_RS21760 (4392337) 4392337..4393050 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JQM62_RS21765 (4393205) 4393205..4393432 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JQM62_RS21770 (4393432) 4393432..4393830 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
JQM62_RS21775 (4393977) 4393977..4394840 + 864 WP_001267508.1 neutral zinc metallopeptidase -
JQM62_RS21780 (4394855) 4394855..4396870 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
JQM62_RS21785 (4396944) 4396944..4397642 + 699 WP_000679812.1 esterase -
JQM62_RS21790 (4397752) 4397752..4397952 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T196771 WP_000911330.1 NZ_CP071711:4393432-4393830 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T196771 NZ_CP095412:c51908-51591 [Blastococcus sp. PRF04-17]
ATGCGCCCGATCCACCTGGCCAGCCTGGACAAGACCCGACCCGTTCTGATCCTGACGCGGGAACTGGTGCGTCCGCACCT
CGCTCGCGTCACCGTCGCACCGATCACGAGCACCATCCGGGGATTGTCGACCGAGGTGCTCGTCGGACCGGTCAACGGCC
TGGATCATCCGAGCGTCATCAGCTGCGACAACGTCGCCACGATCCCCACCGCGGCACTGGGCCGGCAGATCGGCCGCCTC
CTGCCCGAGCAGGAGCCACTTCTCACGGCTGCGCTGCACGCTGCGTTCGACCTGGAGGAGCTGCCGCCGCTCCGTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT196771 WP_000450524.1 NZ_CP071711:4393205-4393432 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT196771 NZ_CP095412:c52147-51908 [Blastococcus sp. PRF04-17]
ATGACCACCCAGATCGCCGTCCGACTTCCCGAGGAGCTCGTCGAGTTCGTCGACCGCCTGGTGTCCGACGGTCGCGCTCC
GTCGCGAGCGGCAGTCGTGAGCCGGGCGCTGCACCGAGAGCTCCGCCGGGAGGTCGCCGCCCGGGACGCAGCCATCCTCG
CCGCCACGGGGACCGAAGCCGACGACCTCGACGAGCTCGCTCGATACGGCGCACGTGTGCCGCTCGACGATCTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References