Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3697234..3698066 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag JQM62_RS18275 Protein ID WP_000854753.1
Coordinates 3697234..3697608 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9QGA8
Locus tag JQM62_RS18280 Protein ID WP_001280948.1
Coordinates 3697698..3698066 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS18245 (3692378) 3692378..3693016 + 639 WP_001145628.1 DUF1076 domain-containing protein -
JQM62_RS18250 (3693307) 3693307..3694671 + 1365 WP_000953522.1 EspK/GogB family type III secretion system effector -
JQM62_RS18255 (3694729) 3694729..3695007 + 279 WP_012816821.1 hypothetical protein -
JQM62_RS18260 (3695874) 3695874..3696443 - 570 WP_001290247.1 DUF4942 domain-containing protein -
JQM62_RS18265 (3696540) 3696540..3696737 - 198 WP_000839281.1 DUF957 domain-containing protein -
JQM62_RS18270 (3696749) 3696749..3697237 - 489 WP_000777552.1 DUF5983 family protein -
JQM62_RS18275 (3697234) 3697234..3697608 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
JQM62_RS18280 (3697698) 3697698..3698066 - 369 WP_001280948.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQM62_RS18285 (3698229) 3698229..3698450 - 222 WP_000692311.1 DUF987 domain-containing protein -
JQM62_RS18290 (3698513) 3698513..3698989 - 477 WP_001186726.1 RadC family protein -
JQM62_RS18295 (3699005) 3699005..3699490 - 486 WP_000849571.1 antirestriction protein -
JQM62_RS18300 (3699545) 3699545..3700363 - 819 WP_001234620.1 DUF932 domain-containing protein -
JQM62_RS18305 (3700463) 3700463..3700696 - 234 WP_001119729.1 DUF905 family protein -
JQM62_RS18310 (3700775) 3700775..3701137 - 363 Protein_3586 IrmA family protein -
JQM62_RS18315 (3701184) 3701184..3702397 + 1214 WP_162860179.1 IS3 family transposase -
JQM62_RS18320 (3702439) 3702439..3702543 - 105 Protein_3588 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T196768 WP_000854753.1 NZ_CP071711:c3697608-3697234 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T196768 NZ_CP095408:c30392-30090 [Acinetobacter pittii]
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13609.50 Da        Isoelectric Point: 7.3991

>AT196768 WP_001280948.1 NZ_CP071711:c3698066-3697698 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT196768 NZ_CP095408:c30089-29808 [Acinetobacter pittii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QGA8

References