Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3649481..3650265 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3E1VW18
Locus tag JQM62_RS17980 Protein ID WP_050869709.1
Coordinates 3649481..3649807 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID C7BUQ9
Locus tag JQM62_RS17985 Protein ID WP_001285644.1
Coordinates 3649897..3650265 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS17950 (3644776) 3644776..3645753 + 978 WP_000633206.1 type II secretion system minor pseudopilin GspK -
JQM62_RS17955 (3645750) 3645750..3646928 + 1179 WP_000094966.1 type II secretion system protein GspL -
JQM62_RS17960 (3646930) 3646930..3647466 + 537 WP_000942788.1 GspM family type II secretion system protein YghD -
JQM62_RS17965 (3647809) 3647809..3648651 - 843 WP_001378387.1 DUF4942 domain-containing protein -
JQM62_RS17970 (3648736) 3648736..3648933 - 198 WP_000839243.1 DUF957 domain-containing protein -
JQM62_RS17975 (3648945) 3648945..3649433 - 489 WP_000761729.1 DUF5983 family protein -
JQM62_RS17980 (3649481) 3649481..3649807 - 327 WP_050869709.1 TA system toxin CbtA family protein Toxin
JQM62_RS17985 (3649897) 3649897..3650265 - 369 WP_001285644.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQM62_RS17990 (3650428) 3650428..3650649 - 222 WP_000692319.1 DUF987 domain-containing protein -
JQM62_RS17995 (3650712) 3650712..3651188 - 477 WP_001368782.1 RadC family protein -
JQM62_RS18000 (3651204) 3651204..3651677 - 474 WP_001368734.1 antirestriction protein -
JQM62_RS18005 (3651771) 3651771..3652016 - 246 WP_001164975.1 hypothetical protein -
JQM62_RS18010 (3652016) 3652016..3652567 - 552 Protein_3526 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12208.98 Da        Isoelectric Point: 6.8512

>T196767 WP_050869709.1 NZ_CP071711:c3649807-3649481 [Escherichia coli]
MKTLPDTHVREASRCPSPVIIWQTLLTRLLDQHYGLTLKDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDN

Download         Length: 327 bp

>T196767 NZ_CP095408:c30089-29808 [Acinetobacter pittii]
ATGGCTATCAAACTTCGTAAATGGGATAGTGCTGAGCATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCTGCATTCATTGCTAAAGCTTTAGGTAACATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGTCTAGGCCGAGAAAGTCTTTACAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCGATTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13533.31 Da        Isoelectric Point: 5.0235

>AT196767 WP_001285644.1 NZ_CP071711:c3650265-3649897 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGVCLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT196767 NZ_CP095408:c30392-30090 [Acinetobacter pittii]
ATGTACTCAATATATACCACAGAAGCCTTTGATGATTGGTTTACCAAGTTAAAAGATCAACAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGGAACTTTGGAGATACTGAACCAGTCGGTGAAGGTGTTTCTGAGTTACGTTTCT
TCTTTGGACCTGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTCGTTATTCTCTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3E1VW18

Antitoxin

Source ID Structure
AlphaFold DB C7BUQ9

References