Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3129394..3130025 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag JQM62_RS15375 Protein ID WP_001259385.1
Coordinates 3129394..3129669 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag JQM62_RS15380 Protein ID WP_000593554.1
Coordinates 3129666..3130025 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS15360 (3124398) 3124398..3125465 + 1068 WP_000361467.1 HlyD family secretion protein -
JQM62_RS15365 (3125462) 3125462..3128197 + 2736 WP_000149167.1 ribosome-associated ATPase/putative transporter RbbA -
JQM62_RS15370 (3128197) 3128197..3129321 + 1125 WP_001216257.1 ABC transporter permease -
JQM62_RS15375 (3129394) 3129394..3129669 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
JQM62_RS15380 (3129666) 3129666..3130025 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JQM62_RS15385 (3130075) 3130075..3130935 - 861 WP_001131783.1 class II aldolase -
JQM62_RS15390 (3130967) 3130967..3131236 - 270 WP_000933060.1 HPr family phosphocarrier protein -
JQM62_RS15395 (3131226) 3131226..3132734 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
JQM62_RS15400 (3132727) 3132727..3134085 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
JQM62_RS15405 (3134162) 3134162..3134443 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
JQM62_RS15410 (3134440) 3134440..3134913 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3121777..3130025 8248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T196765 WP_001259385.1 NZ_CP071711:3129394-3129669 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T196765 NZ_CP095407:c2945946-2945287 [Acinetobacter pittii]
ATGACAGAACGTGAGTATAGCGAATCTCTCAATCCACAAAAAGCATTGATCTGGAGAATTGTACATCTGGATAATATTGC
TTGGGTTTTGGAACATGGCTTGCACTGTGGCAATAGCCTTACGGCTTCCCCAAATTGGGTACATATTGGTAATACCGAAT
TAATTGATAAAAGAGCAAATCATCCTGTACCAGTTGGACAGGGTGGATACCTGAATGATTATGTACCTTTTTATTTTACG
CCATTTTCTCCCATGCTTTTGAACATCACAACAGGGCGAGGTGGTGTCCGACAGCGTTCTAATGATGAGATTGTCATTCT
CGTATCAAGTCTGCATCGTTTACAGGAATTGAATATGCCGTTTGTATTCACAGATGGTCATGCCTATTATCAATGGTCAA
ATTTCTATACGGATTTAGCTGATTTAGATAAGATTGATTGGCAGATTTTACAGAAAAAAGATTTCAGTCGGGATGTGGAT
GATCCCGCAAAGTTTGAACGTTATCAGGCAGAGGCACTTGTACATCAACATTGTCCGATTGAAGCCCTGCTCGGTATGAT
ATGTTACAATGAGAAAATTAAATCTTTGCTAGAGCAACAATTGCAGCAAGCAAATATTGAAATGCCTGTTTATGTAAGGT
CAGGAGTATATTTTAAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT196765 WP_000593554.1 NZ_CP071711:3129666-3130025 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT196765 NZ_CP095407:c2945290-2944226 [Acinetobacter pittii]
ATGATTCGTTATACGACTGGAAACTTACTGGATGCCCCAGTAGAAGCATTGGTCAATACTGTAAATACAGTAGGGGTCAT
GGGGAAAGGCATTGCTTTGATGTTTAAAGAACGATTCCCTGACAATATGGCTGCCTATCGTCAAGCATGTAAAGAGGGGC
GTGTTCAAACAGGAAAAATGTTTGTTACAGAAACCAATGAATTTTTAGCACCTCGCTGGATCGTTAATTTTCCGACTAAA
CAACACTGGAAAGCCAAATCACAAATTGAATGGGTTGAAGATGGGCTGAAAGATTTAAAACAATTTATTATAGAAAAAAA
TATTTCATCTATTGCGATTCCGCCATTGGGTGCTGGTAATGGTGGGTTAGACTGGCAAGATGTAAAGCCAAAAATAGAAT
CTGCATTGTCAGATTTACTGGATGTGGATGTTCTAATTTTTGAACCGACTGAAAAATATCAGAATATTGCAAAAAATATT
GGTGTGCAAAAACTTACACCAGCTCGGGCTTTGATTGCAGAACTGATTCGTAGGTATGGGGTACTGGGTATGGAATGTAG
TATCCTTGAAATCCAAAAGTTAGCATGGTTTCTACAAAGAGTTATCGAAAAACATAATTTATCCAATGAGTTAAGATTGG
ATTTTCAGGCAAACTATTATGGTCCTTACGCCCACAATCTGACACATCTGCTTAATGCACTAGATGGCAGCTATTTAAAG
TCTGACAAAAGAATCCCTGATTGTGAACCATTGGATGTGATTTGGTTTAATCAACAGGAACAAGGCAAAGTACAAAGCTA
TTTGAACAGTGAGGCAAAAGATTTTGTGCCTGCTCTGGAAGAAGCGGCTGCTTTAATTGAGGGGTTTGAATCACCTTTTG
GAATGGAATTGCTTTCTACAGTAGATTGGCTGATCTATAAAGATGGATGTCAGCCAACGGTTGAATCTATTAAAGATGGG
TTAGCAAATTGGTCTGCTGGTAAACGCTGGGCAGATCGGAAGTTATCTTTATTTAAAGATGAACATATTGAGTATGCTTT
GGATAAGTTACAGAAGTCTATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References