Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2365291..2366126 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name yeeV Uniprot ID F2VI91
Locus tag JQM62_RS11895 Protein ID WP_000854748.1
Coordinates 2365749..2366126 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H0IVG5
Locus tag JQM62_RS11890 Protein ID WP_001339471.1
Coordinates 2365291..2365659 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS11860 (2362127) 2362127..2362582 + 456 WP_000581504.1 IrmA family protein -
JQM62_RS11865 (2362661) 2362661..2362894 + 234 WP_001119729.1 DUF905 family protein -
JQM62_RS11870 (2362994) 2362994..2363812 + 819 WP_001234620.1 DUF932 domain-containing protein -
JQM62_RS11875 (2363867) 2363867..2364352 + 486 WP_000849570.1 antirestriction protein -
JQM62_RS11880 (2364368) 2364368..2364844 + 477 WP_001186727.1 RadC family protein -
JQM62_RS11885 (2364907) 2364907..2365128 + 222 WP_000692345.1 DUF987 domain-containing protein -
JQM62_RS11890 (2365291) 2365291..2365659 + 369 WP_001339471.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQM62_RS11895 (2365749) 2365749..2366126 + 378 WP_000854748.1 TA system toxin CbtA family protein Toxin
JQM62_RS11900 (2366123) 2366123..2366611 + 489 WP_000761721.1 DUF5983 family protein -
JQM62_RS11905 (2366623) 2366623..2366820 + 198 WP_000839281.1 DUF957 domain-containing protein -
JQM62_RS11910 (2366917) 2366917..2367489 + 573 WP_001290246.1 DUF4942 domain-containing protein -
JQM62_RS11915 (2368238) 2368238..2369776 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14179.16 Da        Isoelectric Point: 7.7761

>T196762 WP_000854748.1 NZ_CP071711:2365749-2366126 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T196762 NZ_CP095406:c2293854-2293486 [Lacticaseibacillus paracasei]
ATGTATAAAATTGACTTCTATGAGGATCGCGATGGCTACTCTGAGATCGAAGACTTTCTTGATCAGTTACGCCATAGTCA
TCAAAAAAATAATGTGAGCCTTTTAAACAAAATCACAAAGGAACTCTACATGCTGCAAAATCTTGGTCCGCGCTTACGTG
AACCTCACGCGAAGTTTCTGAAGGGATATGCTTATCCGATCATGGAATTGCGTCCCATGCAAGAAAGAATCTTTTATGCT
GCATGGCAAAAGGATCATTTCGTTTTGCTTCATCACTACACCAAGAAAACAAACAAAACTGATCACAGAGAAATTTTACG
GGCACAGTCTAACCTCGAAGATTGGCTCTCTAGAAAGGAAGAAAATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13517.22 Da        Isoelectric Point: 6.4789

>AT196762 WP_001339471.1 NZ_CP071711:2365291-2365659 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT196762 NZ_CP095406:c2293486-2293226 [Lacticaseibacillus paracasei]
ATGACGACATGGGAAGACTTCAGTCAGAAACTGAAGAAGGACAATCCAGAAAAGTTGGCAATCATCAAAACCTTGGCCGA
TTTAGAAAGTGAACGAATCAAGCAAGGAATCTCTCAAAAGGACTTTGCAGAAAAAATTGGTATGAAACAGCCGCAACTAG
CAAAGATTGAGCGCTTAGACTCTCTTCCGACTCTGGCAACACTCAATCGATACGCGAGAGGGCTTGGAAAAGAAATTCGT
TTATCAATTGTTACTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F2VI91

Antitoxin

Source ID Structure
AlphaFold DB A0A0H0IVG5

References