Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 638703..639498 Replicon chromosome
Accession NZ_CP071711
Organism Escherichia coli strain EC20017429

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag JQM62_RS03270 Protein ID WP_000854914.1
Coordinates 638703..639077 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag JQM62_RS03275 Protein ID WP_001280953.1
Coordinates 639124..639498 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQM62_RS03230 (633707) 633707..634198 - 492 WP_001297187.1 DUF1097 domain-containing protein -
JQM62_RS03235 (634300) 634300..634854 - 555 WP_001001902.1 molecular chaperone YcdY -
JQM62_RS03240 (634878) 634878..635615 - 738 WP_000283664.1 zinc-binding phosphatase -
JQM62_RS03245 (635670) 635670..636608 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
JQM62_RS03255 (637079) 637079..637921 - 843 WP_001280481.1 DUF4942 domain-containing protein -
JQM62_RS03260 (638006) 638006..638203 - 198 WP_000839282.1 DUF957 domain-containing protein -
JQM62_RS03265 (638215) 638215..638706 - 492 WP_000976857.1 DUF5983 family protein -
JQM62_RS03270 (638703) 638703..639077 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
JQM62_RS03275 (639124) 639124..639498 - 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JQM62_RS03280 (639661) 639661..639882 - 222 WP_000692323.1 DUF987 domain-containing protein -
JQM62_RS03285 (639945) 639945..640421 - 477 WP_001186738.1 RadC family protein -
JQM62_RS03290 (640437) 640437..640922 - 486 WP_000214398.1 antirestriction protein -
JQM62_RS03295 (641013) 641013..641831 - 819 WP_001234682.1 DUF932 domain-containing protein -
JQM62_RS03300 (642171) 642171..643241 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
JQM62_RS03305 (643238) 643238..644143 - 906 WP_000203541.1 diguanylate cyclase regulator RdcB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T196755 WP_000854914.1 NZ_CP071711:c639077-638703 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T196755 NZ_CP095384:c496476-496291 [Lacticaseibacillus rhamnosus]
ATGCAGCGTCAAGCTCATGTAAAATTAGCTTCTTTACACGGCCATGCTTTAAGGGGTGCTCACAGCGGCGAACGAGCATT
GCATATTGCTCCTGATTGGCTTCTGGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT196755 WP_001280953.1 NZ_CP071711:c639498-639124 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT196755 NZ_CP095384:c496776-496504 [Lacticaseibacillus rhamnosus]
ATGGCAAAAGAATCCCGTATCCGCAATTGGATTAACACAATAACCAAAAAACGAGCTCTCCATGTTCTTAATCGTCTGGG
ACTAGAGAGATTCTCGGCTATTAACATGTATTCGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACTTGAAATGT
CATTCGCCGATCAGCTTCGATTTGCAGAAGCAGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTTGGTGCTTTG
ATGAAGGATTTATACAATGATGTTGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References