Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1102864..1103458 Replicon chromosome
Accession NZ_CP071706
Organism Pseudomonas donghuensis strain P482

Toxin (Protein)


Gene name relE Uniprot ID A0A2M9VPP2
Locus tag BV82_RS05025 Protein ID WP_036993896.1
Coordinates 1102864..1103157 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2M9VPL5
Locus tag BV82_RS05030 Protein ID WP_010223489.1
Coordinates 1103159..1103458 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV82_RS05005 (BV82_0226) 1099631..1100602 - 972 WP_036993895.1 FecR family protein -
BV82_RS05010 (BV82_0227) 1100595..1101128 - 534 WP_010223492.1 RNA polymerase sigma factor -
BV82_RS05015 (BV82_0228) 1101187..1101867 - 681 WP_145959264.1 hypothetical protein -
BV82_RS05020 (BV82_0229) 1102202..1102438 - 237 WP_081492801.1 hypothetical protein -
BV82_RS05025 (BV82_0230) 1102864..1103157 + 294 WP_036993896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV82_RS05030 (BV82_0231) 1103159..1103458 + 300 WP_010223489.1 putative addiction module antidote protein Antitoxin
BV82_RS05035 (BV82_05035) 1103481..1104107 - 627 Protein_992 bestrophin family ion channel -
BV82_RS05040 (BV82_0233) 1104160..1104636 - 477 WP_036993897.1 GNAT family N-acetyltransferase -
BV82_RS05045 (BV82_0234) 1104777..1105289 + 513 WP_036993898.1 superoxide dismutase family protein -
BV82_RS05050 (BV82_0235) 1105362..1105667 + 306 WP_036993904.1 HigA family addiction module antitoxin -
BV82_RS05055 (BV82_0236) 1106247..1107113 - 867 WP_036993899.1 OST-HTH/LOTUS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-97)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10685.48 Da        Isoelectric Point: 10.7515

>T196747 WP_036993896.1 NZ_CP071706:1102864-1103157 [Pseudomonas donghuensis]
MKYSVLQTPRFTSWLISVRDMRARVAIARRIERVTAGNLGDVKSVGGQVCEMRIDVGAGYRVYFTARDGVVIVLLAGGDK
SSQSVDIQLARKLAKEI

Download         Length: 294 bp

>T196747 NZ_CP095280:c3475648-3474995 [Aeromonas hydrophila]
ATGGCCTATGACTATAGCCAGAGCCTGAATCCGCAGAAGGCGCTGATATTCCGGATCGTGCATCGGGATAACCTGGAATG
GATCCTGACCCATGGCCTGTGGGCGGGGAATGGTCAGCAGCAAAACCCGCACTGGGTGCATATCGGGTTGCCGGAGCTGA
TTGCCAAGCGCGCACGCCATCCGGTGCCGCTGGCGCCTTACGGCGTGTTGAATGACTATGTGCCCTTCTACTTCACGCCG
TTTTCGCCCATGCTCAGCAATATTCACTCGGGGCGCGGTGTTCCCCAGCGTGAAAATGATGAAATCCTGATCCTGGTTTC
CAGCCTGCATCGCATGGCTGAATTGGGGCTACCGTTTGTGTTTACCGATAGCCATGCCTATTACCAGTGGGCCAATTTCT
ATGTCGACCTTGGCGATCTGGGGCGGATTGACTGGCCACTGTTGCAGCGCCGTGACTTCAAGCGTGATGCGGAAGATTTG
AGCAAGCTGGAACGCTATCAGGCCGAGGCCTTGATCCATCAACATTGCCCCATCGAGGCGTTGCTGGGCGTGGTGTGTTA
CAACGAAGAAATAAAGAACAGCGTGGAACAATGCATGAATCGGGTGGGGGTCTCGCGCCCCGTCTATGTCCGTGATGGGT
GGTATTTCAGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10629.21 Da        Isoelectric Point: 6.2132

>AT196747 WP_010223489.1 NZ_CP071706:1103159-1103458 [Pseudomonas donghuensis]
MSLSLTTFDMAALLDSDETISEYLSQVLADGDHDELIRALGYIAKARGMSQIATASGLGRESLYKALTPGAKPRFDTVLK
VIRALGIDLLAHPHASSRL

Download         Length: 300 bp

>AT196747 NZ_CP095280:c3474959-3473934 [Aeromonas hydrophila]
GTGGAAGCACTGGTGAATACCGTCAACACAGTCGGTGTCATGGGCAAGGGGATCGCCTTGATGTTCAAGGAGCGGTTCCC
GGCCAATATGCGCGCCTATGCCGAGGCGTGCAAGCAGGGTGACGTCGTCACCGGCAAGATGTTTATTACCCAGACGGGTG
AGCTGCTGGGGCCGCGCTGGATCGTGAATTTTCCGACCAAACAGCACTGGCGCAATCCGGCACAGATGGCGTGGATCCAG
GAGGGTTTGCAGGATCTGCGGGCCTGGTTACAGGCGCAGCAGGTCTCTTCGATTGCCATTCCGCCGCTGGGGGCTGGCAA
CGGTGGTCTGCCTTGGCCAGAGGTCAAACAGGCGATCGAAACGGCACTGGGCGATCTGGATATCGATATCCTGCTCTATG
AGCCCAGTCGCCAATACCAAAATGTGGCCAAGCGCGGCGGGGTGGCGGAGCTGACTCCGGCTCGGGCCCTGATTGCTGAA
CTGGTACGTCGCTACTGGTTTTTAGGGATGGAGTGCAGCTTGCTGGAAATCCAGAAGCTGGCCTGGTTTCTGGCGCGGGT
CATTGGCCGCAACCCGCTGGGGGATCCGCTGCAGTTGCAGTTTAAGGCCCATCGTTATGGCCCTTATGCCAACAATCTGA
CCCATCTGCTCAATGCGATGGACGGCAGTTATCTGCAGTCCGACAAGCGCATCCCGGATAGCAAGCCGTTTGATGTCATC
TGGTTTAATGAGGCTAAAAAACAAGAGCTTGCCGTTTATCTCCAGACCGAGGCCAAAGCATTTTTACCGATACTGGAGCA
GACGACCGCGTTAATCGATGGTTTTGAGTCGCCCTATGGCATGGAGTTATTGGCCACGGTGGATTGGTTGATCGCCGAAG
AGGGCTGTGCGCCGACGCTGAGCGCGCTGCGAGAGGGGTTGCATCGCTGGCCAGCGGGAACCCCGTGGGGTGAGCGCAAG
GCGCGGCTGTTTGATGATCGCAGTCTGCAGATCGCCTTGACCCGTTTGCAGCAGGGATTGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2M9VPP2

Antitoxin

Source ID Structure
AlphaFold DB A0A2M9VPL5

References