Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1794135..1794866 Replicon chromosome
Accession NZ_CP071698
Organism Actinobacillus pleuropneumoniae strain SC1810

Toxin (Protein)


Gene name tacT Uniprot ID A0A448U107
Locus tag J3K87_RS08325 Protein ID WP_005602211.1
Coordinates 1794135..1794602 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag J3K87_RS08330 Protein ID WP_005619269.1
Coordinates 1794606..1794866 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3K87_RS08300 (J3K87_08280) 1789494..1789865 - 372 WP_005598830.1 CrcB family protein -
J3K87_RS08305 (J3K87_08285) 1789868..1790932 - 1065 WP_039709309.1 MFS transporter -
J3K87_RS08310 (J3K87_08290) 1791027..1792136 + 1110 WP_252590408.1 anhydro-N-acetylmuramic acid kinase -
J3K87_RS08315 (J3K87_08295) 1792190..1793104 + 915 WP_009875244.1 N-acetylmuramic acid 6-phosphate etherase -
J3K87_RS08320 (J3K87_08300) 1793171..1794052 - 882 WP_005598838.1 50S ribosomal protein L11 methyltransferase -
J3K87_RS08325 (J3K87_08305) 1794135..1794602 - 468 WP_005602211.1 GNAT family N-acetyltransferase Toxin
J3K87_RS08330 (J3K87_08310) 1794606..1794866 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
J3K87_RS08335 (J3K87_08315) 1794987..1796447 - 1461 WP_237593341.1 metalloprotease TldD -
J3K87_RS08340 (J3K87_08320) 1796577..1797836 + 1260 WP_237593342.1 tRNA lysidine(34) synthetase TilS -
J3K87_RS08345 (J3K87_08325) 1797863..1798075 - 213 WP_237593654.1 DUF5389 family protein -
J3K87_RS08350 (J3K87_08330) 1798155..1799048 - 894 WP_237593343.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17192.19 Da        Isoelectric Point: 8.9312

>T196744 WP_005602211.1 NZ_CP071698:c1794602-1794135 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

>T196744 NZ_CP095280:2571809-2572063 [Aeromonas hydrophila]
ATGAGATTAATTTTTTCCGATGATGCATGGGAAGATTATCTGTTCTGGCAAAAACAAGACCGCCGCATGGTTGATCGAAT
TAACAAGCTAATTAAAGAAACCACCCGAGAGCCTTTCTCTGGAGTGGGCAAGCCAGAGCCATTAAAACATGCTTTGGCCG
GTTATTGGTCTCGTCGAATTACGGATGAGCACCGAATGGTTTACAAAGTGGCGGATGATGCCCTTTGGATCGTTCAACTC
AAGTACCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT196744 WP_005619269.1 NZ_CP071698:c1794866-1794606 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp

>AT196744 NZ_CP095280:2571561-2571812 [Aeromonas hydrophila]
ATGGACGCTATCACTTACACACACGCCCGCGCCAACCTGGCTGGAACCATGGATCGTGTTTGCAACGATCATGAGCCGGT
GATCATCACACGTAACGGCGACCAATCGGTTGTGATTCTCTCGCTGGAAGATTTCCAGGCGCTGGAAGAAACTGCGTATC
TGCTGCGCAGCCCCGCCAACGCCAAGCGGCTTTTCAAGTCGATCGAGCAACTTGAAGCGGGCCGAGGACAGGCGCGGGAG
TTGGCCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448U107

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References