Detailed information of TA system TA196742

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 1494230..1494738
• Replicon: chromosome
• Accession: NZ_CP071698
• Organism: Actinobacillus pleuropneumoniae strain SC1810

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J3K87_RS06840
• Protein ID: WP_237593298.1
• Coordinates: 1494478..1494738 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J3K87_RS06835
• Protein ID: WP_017357689.1
• Coordinates: 1494230..1494481 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J3K87_RS06795 (J3K87_06775)	1489765..1490313	-	549	WP_237593297.1	type IV pilus biogenesis/stability protein PilW	-
J3K87_RS06800 (J3K87_06780)	1490367..1491548	-	1182	WP_005608495.1	bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN	-
J3K87_RS06825 (J3K87_06805)	1492453..1493892	+	1440	WP_237592596.1	glutamate--tRNA ligase	-
J3K87_RS06835 (J3K87_06815)	1494230..1494481	+	252	WP_017357689.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
J3K87_RS06840 (J3K87_06820)	1494478..1494738	+	261	WP_237593298.1	Txe/YoeB family addiction module toxin	Toxin
J3K87_RS06845 (J3K87_06825)	1494897..1495064	-	168	WP_005598320.1	Trm112 family protein	-
J3K87_RS06850 (J3K87_06830)	1495066..1496046	-	981	WP_005608502.1	tetraacyldisaccharide 4'-kinase	-
J3K87_RS06855 (J3K87_06835)	1496140..1497399	-	1260	WP_005598324.1	ATP-dependent protease ATP-binding subunit ClpX	-
J3K87_RS06860 (J3K87_06840)	1497399..1497989	-	591	WP_005598326.1	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	-
J3K87_RS06865 (J3K87_06845)	1498111..1498503	+	393	WP_005620423.1	SufE family protein	-
J3K87_RS06880 (J3K87_06860)	1498862..1499635	-	774	WP_237593300.1	DNA polymerase III subunit epsilon	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10439.99 Da
• Isoelectric Point: 8.0109

>T196742 WP_237593298.1 NZ_CP071698:1494478-1494738 [Actinobacillus pleuropneumoniae]
MKLTFSSNSWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Nucleotide

• Length: 261 bp

>T196742 NZ_CP095277:35376-35900 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGCCAACCTGACCATTGAGATGTTTTCAGAAGAGGCTGTATATGATTTCTCATGCTTCGACTGCGGAGAAACGTCTCT
CAATGATTTTCTTAACAATCGCCTCGCCCAGCAACACAGCGGGCGTATATTACGCGGATATCTGCTTCTGACGAGAGATC
CGATACCGAAAGTGATGGGGTTTTACACGTTGTCCGGGAGCTGCTTTGCAAGAAACACGCTTCCTTCCAACACTCAACAG
CGTAAAGTCCCCTATTCCGACGCCCCAAGCGTTACGCTCGGTCGTCTGGCAATAGACAAAAGTATCCAGCGACAAGGGTA
TGGGGAAACGCTGGTGGCACATGCGATGAAAGTGGTATACCGGGCTTCCCTGGCCGTTGGGATCTACGCTTTGTTTGTTG
ACGCCAAAAATGAGAATGCGATGCGGTTTTATAAGCAGTTAGGCTTTACCCCTCTTACGGGTGATAACGCCAATTCGCTG
TTCTATCCCACAAAAGGCATTGAGAAGTTGTTTGGTGGAAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9336.62 Da
• Isoelectric Point: 4.5659

>AT196742 WP_017357689.1 NZ_CP071698:1494230-1494481 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVTEDFEPVLITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Nucleotide

• Length: 252 bp

>AT196742 NZ_CP095277:35103-35372 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTCAGCACTGAAAAAACAGCGCATCGATCTCAGATTAACCGACGACGACAAGAGCATGATCGAAGAAGCTGCGGCAAT
GACCAACCAGACAATTACTCAGTTTATGGTTGCCAGTGCCTCTGAACGTGCTGCGGAAGTGATAGAGCAACATCGTCGCC
TGATTCTTAGCGAAGAGTCATGGAATATAGTGATGGATGCCATCAGTAACCCGCCTGCACCGAATGATAGGCTGAAACGA
GCTGCCGAGCGTCTACAAAGCATGGAGTAA