Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2411846..2412449 Replicon chromosome
Accession NZ_CP071697
Organism Streptococcus suis strain 1112S

Toxin (Protein)


Gene name hicA Uniprot ID A0A0N0DNR4
Locus tag J1N58_RS11530 Protein ID WP_002941795.1
Coordinates 2412258..2412449 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0Z8F1F3
Locus tag J1N58_RS11525 Protein ID WP_002941801.1
Coordinates 2411846..2412223 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J1N58_RS11505 2407532..2408071 - 540 WP_024378798.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
J1N58_RS11510 2408081..2408938 - 858 WP_024378799.1 helix-turn-helix domain-containing protein -
J1N58_RS11515 2409020..2410303 - 1284 WP_024378800.1 insulinase family protein -
J1N58_RS11520 2410300..2411553 - 1254 WP_024375814.1 insulinase family protein -
J1N58_RS11525 2411846..2412223 - 378 WP_002941801.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J1N58_RS11530 2412258..2412449 - 192 WP_002941795.1 type II toxin-antitoxin system HicA family toxin Toxin
J1N58_RS11535 2412881..2413294 - 414 WP_105182147.1 hypothetical protein -
J1N58_RS11540 2413756..2414316 - 561 WP_207560384.1 hypothetical protein -
J1N58_RS11545 2414343..2414570 - 228 WP_105182150.1 hypothetical protein -
J1N58_RS11550 2414924..2415385 - 462 WP_207560385.1 hypothetical protein -
J1N58_RS11555 2415382..2416218 - 837 WP_207560386.1 ATP-binding protein -
J1N58_RS11560 2416231..2417067 - 837 WP_207560387.1 phage replisome organizer N-terminal domain-containing protein -
J1N58_RS11565 2417057..2417335 - 279 WP_105182154.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-106)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6989.26 Da        Isoelectric Point: 10.5552

>T196740 WP_002941795.1 NZ_CP071697:c2412449-2412258 [Streptococcus suis]
MPLTGKEMAKLAEANGWKEIRVNGSHHHFKKEGFSKIVTIPVHGNKDLGKGLEKKILKDLGLL

Download         Length: 192 bp

>T196740 NZ_CP095276:c4635655-4635470 [Enterobacter hormaechei subsp. xiangfangensis]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14181.00 Da        Isoelectric Point: 4.2621

>AT196740 WP_002941801.1 NZ_CP071697:c2412223-2411846 [Streptococcus suis]
MLKSYPAIFHKDEQGYWVEFPEFSGGTQGDNLEEAMYNAREFLESSIALYIDEGMELPKASDIKELSAPDGFVSMIQADP
TPYIKNNKAIRKNVTVPEWLTKLADREGLNYSEILTTALETRLQV

Download         Length: 378 bp

>AT196740 NZ_CP095276:c4635455-4635051 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0DNR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8F1F3

References